Objectives: Understand the key characteristics of a crosslinked HA filler gel driving safety and performance.
Introduction: HA fillers are the most successful and most described fillers. There are numerous brands on the market and to differentiate products, scientific publication or companies’ promotion give a strong focus on rheological properties of the crosslinked HA gels. This focus can lead to very technical concepts and product characteristics far from the expectation and needs of clinical practitioners.
Conclusion: In your clinical practice, rheology should not be seen as a stand-alone characteristic; it is intertwined with the other key characteristics of the crosslinked HA gel. Other key characteristics of an HA fillers are relevant to safety and performance: concentration, cohesivity/hydrophily, purity, gel particles size, and also the device. Those characteristics will drive what you can expect as clinical performance of a filler. Some will also play a key role with regards to hyaluronidase digestion and this is of particular importance when considering situation with accidental vascular occlusions.
Disclosures
Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): SYMATESE
Were you provided with any honoraria, payment or other compensation for your work on this study?
Yes
Please specify entities (individual, company, society): SYMATESE
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
Yes
Please specify entities (individual, company, society): SYMATESE
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work is presented thanks to the support of: SYMATESE