Dr. Inigo DE FELIPE Y GARATE
Dermatologista
Breaking the borders of the unknown: new indications of ASC-exosomes for alopecia (educational grant from ExoCoBio)
Objectives: To explore new applications of Nanofat and MSC and ASC exosomes in inflammatory and immune Alopecia
Introduction: Mesenchymal stem cells (MSC) and Adipocyte derived stem cells (ASC) are the basis of regenerative medicine through Nanofat transfer and through signaling between cells via exosomes.
Some of these substances include micro-RNA known to have anti-inflammatory properties.
Materials / method: We have used MSC exosomes in 175 patients with Alopecia conditions such as Androgenetic Alopecia both in men and women, Lichen plano-pilaris, Frontal fibrosing alopecia, and Alopecia Areata. MSC Exosomes were injected alone or in combination with Nanofat and other drugs intradermally, applied topically or applied on skin treated previously with microneedling or Er:YAG fractional session.
Results: We show herein the results obtained in these skin conditions and discuss the probable mechanism of action.
Conclusion: Promising results can be obtained with Nanofat and MSC exosomes. These procedures are very safe.
