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Objectives: Objectives: 1.To evaluate the result of vulvovaginal rejuvenation by using combination treatment of vaginal co2 laser and exosome 2.To evaluate safety of plant stem cell-derived exosomes for vulvovaginal rejuvenation Introduction: Nowadays all age women concern about genital wellness.The aim of vulvovaginal rejuvenation is not only for aesthetics but also for functional and sexual function problems.Vaginal Co2 laser has been use for many years for improve vaginal laxity, SUI,Vaginal dryness.Exosomes are the most important mediators for intercellular communication. The triple functions of regeneration, rejuvenation, and anti-inflammation of exosomes have been well-known number of research. Exosomes are being developed as next-generation regenerative therapeutics and aesthetics to improve the quality of life of all women Materials / method: 1. Evaluate VHI before treatment 2. Apply the numbing cream 45 minute at vulvar area 3. Use Co2 laser for vulvovaginal rejuvenation intravaginal and vulvar area 4. Apply the exosome intravaginal and vulvar area. Gentle message until exosome was absorbed 5. Follow the protocol of vaginal Co2 laser, 3 sessions, 4 weeks apart for 1st and 2nd session and 6 weeks apart for 3rd session Results: Results: 1.Youthful appearance of vulvar area 2.Improve in vaginal dryness, tightening, improve in SUI 3.Improve in VHI 4.Not seen any complication Conclusion: Combined treatment of vaginal Co2 laser and exosome for vulvovaginal rejuvenation improve in aesthetic and functional aspect. Patient satisfy with the results and not seen any complication