摘要

Objectives: We wonder what the durability of new hybrid is injectable, and what is the safety of this hybrid with hyaluronic acid (HA) and calcium hydroxyapatite. For this reason, analyse 3272 patients and we did sonography study in 3 women 18 months after infiltration. Introduction: Treatments with injectable hybrids combine the capacities of hyaluronic acid together with calcium hydroxyapatite. Retrospective study with 3272 patients was done to analyse safety and efficacy of commercial hybrid fillers. Although there are various studies on the durability of hyaluronic acid fillers according to their rheology, and calcium hydroxyapatite; little is known about the degradation of hybrid fillers; although some studies analyse duration only with visual effects, we show 3 cases to analyse the long-term durability during 18 months by ultrasound. Materials / method: Our study includes 3272 patients. Three women between 48-55 years old were studied by sonography at 18 months after infiltration. Theses woman were injected with 1 syringe of Harmonica (1,25ml) per each hemi-face; the hybrid was infiltrated into the zygomatic, ramus and jaw line, and photography follow was done after, post-immediately, 1 month and 1.5 years after injection. We study one case of late inflammatory response with sonography 15MHz probe. Results: Our experience in 3272 patients indicate that infiltration with this commercial hybrid filler shown normal acute inflammation after infiltration and only 3 patients shown late inflammatory process, which effects were resolve several days after of the nodule appeared. The three patients shown an aesthetic improvement 1.5 months after treatment, which were visible until 18 months after. Through the ultrasound study, the presence of a material in hyperechogenic bands was observed in the injection regions ; showing that after 18 months the commercial injectable hybrid is present. Conclusion: The ultrasound and photographic study show that injectable hybrids until 18 months after infiltration, obtaining a greater aesthetic result than that described only for hyaluronic acid fillers and calcium hydroxyapatite separately. Late events with hyaluronic acid are estimated in 0.01-0.1%. Our study showed 0.09% incidence and is correlated with adverse effects with HA.