摘要

Objectives: this study aims to assess the outcomes and safety of the Guided Superficial Enhanced Fluid Fat Injection (SEFFI) technique for facial rejuvenation. Through a retrospective analysis of cases from multiple Italian centers, the study seeks to evaluate the efficacy of guided SEFFI in enhancing facial aesthetics, improving skin quality, and ensuring patient satisfaction. This investigation contributes valuable insights into the applicability and benefits of SEFFI Introduction: Clinically, aging manifests as fine lines and wrinkles, a loss of elasticity, dyschromia, epidermal thinning, and increased coarseness . The volumetric loss of contours and angularity in the face are also visible due to tissue atrophy within the deep layers of the skin. Regenerative therapy exploits the properties of the cells of the stromal vascular fraction (SVF) of the adipose tissue to counteract these aging-associated changes. In this study, we present data retrospectively collected by ten physicians who carried out more than 2300 guided SEFFI procedures in various anatomic face area Materials / method: This study is a retrospective analysis of data obtained from 2365 healthy patients, whom 2123 were females aged, on average, 49.2 years old (range: 38–65 years), and 242 were males aged, on average, 47.0 years old (range: 41–53 years). Patients were treated in 10 different professional centers for aesthetic physicians and surgeons, with the guided SEFFI technique. The follow-up of the cases was between 4 and 6 months depending on the center. Results: guided SEFFI was used alone in more than 60% of the patients and in all facial areas. In about one-tenth of the patients, guided SEFFI was combined with a botulin toxin treatment or hyaluronic acid filling. Other procedures were used more rarely. Ecchymosis in the donor or injection sites was the most frequent adverse event but was only observed in 14.2% and 38.6% of the patients, respectively. Conclusion: The guided SEFFI technique is standardized and minimally invasive, leading to very few complications. It constitutes a promising antiaging medical treatment that combines effectiveness, safety, and simplicity.