摘要

Objectives: 1. Mesotherapy – the importance of active substances (vitamins, amino acids, and growth factors) in skin physiology and skin aging. 2. Delivering active substances by topical application, injection, or with the assistance of microneedling and energy-based devices (focusing on mechanical thermal action) 3. Implication in skin rejuvenation (stand-alone/adjuvant), decreasing post-procedural downtime, and treating skin pathologies (stretch marks and hyperpigmentation) Introduction: Most of the efforts in aesthetic medicine are directed toward quantity improvement, such as increasing collagen fibers, decreasing amount of pigment, and increasing volume in lost spaces. Skin beauty is also depended on its quality and functionality. For example, high collagen can be also found in scars. Some pathologies of the skin, like stretch marks and hyperpigmentation, require changing skin behavior and quality rather than quantity, and some aesthetic interventions can be potentiated if skin cells will be supplied with their nutrients. Materials / method: A literature review was conducted to compare different active substances that are important for skin function, and their clinical implications. Afterward a literature review was conducted to evaluate different delivery modes of active substances (mesotherapy). This knowledge was combined with my practical experience and my protocols that involve the combination of mesotherapy with other procedures and as stand-alone treatments. Results: Vitamins, amino acids, minerals, and growth factors (self-produces as PRP, or synthetic) are important factors in many reactions in our skin. 1. Collagen synthesis require the continuous supplement of vitamins and antioxidant for its correct and efficient laydown. 2. Skin hyperpigmentation is partly created by the lack of antioxidation materials in the tissue. 3. Stretch marks and scars are low quality skin conditions that will benefit from the improvement of their quality. 4. Fat can become thinner only by supplementation of substance that increases its metabolism. Conclusion: • In order to increase the efficacy of our treatments we must supply the skin with the correct nutrients that are needed for performing its functions. • Different methods exist for delivering of active substances into the skin and different consideration should be taken into account in each of them. • Post-procedural downtime might be shorter if the skin is supplied with the correct ingredients for faster healing.