摘要

Objectives: 1. Explain exosomes and hybrasomes 2. Present results in human clinical trials 3. Make recommendations for optimal clinical applications Introduction: Exosomes contain various growth factors, proteins, and genetic material that may contribute to tissue regeneration. This regenerative potential is of interest in plastic surgery for promoting wound healing, reducing scarring, and enhancing tissue repair. In addition to tissue regeneration, exosomes play a role in stem cell activation, possess anti-inflammatory properties, stimulate collagen production, enhance fat transfer and minimize scarring. They can be delivered topically or via minimally invasive methods as a non-surgical option for tissue regeneration. Materials / method: To create a product that can be registered and used as a cosmeceutical, a unique technique was employed to develop a bovine umbilical cord tissue product hybridized with a liposomal agent. This new product is called a hybrasome and has now been tested in 100’s of patients by independent dermatology research companies. The product was compared to 0.02% retinol as well as to a leading consumer brand, Augustine Bader in a split face study. In addition, we have now used the product in 50 patients with outstanding feedback. Results: The results have shown that the hybrasome cream significantly outperforms both Retinol as well as Augustine Bader. Results of these studies will be presented in detail. There have been virtually no side effects. Conclusion: Hybrasome creams represent a new paradigm in the use of subcellular particles such as exosomes. Advantages include, FDA registration, the “youthful” messages of cord tissue exosomes” and there prolonged shelf life. Compared to both retinol as well as a leading consumer brand, hybrasomes were markedly better in virtually all categories of skin aging.