摘要

Objectives: Female pattern hair loss (FPHL) is a common form of non-scarring hair and often a source of significant psychological distress. Autologous platelet aggregates have been proposed as a potential therapy to treat FPHL, either alone or in combination treatment. In this study, we aimed to evaluate the application of injectable platelet-rich fibrin (i-PRF) as a novel hair loss solution, with a review of literature data. Introduction: Various trials have been conducted on the management of female pattern hair loss, but the outcomes often seem to be limited. Platelet-rich plasma (PRP) has a well-established role as adjunctive therapy in androgenetic alopecia but there are many limitations of it. In an attempt to overcome the shortcomings of PRP, liquid platelet-rich fibrin (PRF) is guaranteeing a prolonged release of growth factors and cytokines and a three-dimensional scaffold structure for hair cells regrowth. Materials / method: 11 patients were enrolled in this scalp trial underwent 4-monthly intradermal injections of i-PRF. Under all aseptic precautions, the tubes were centrifuged at 800 rpm for four minutes. The i-PRF obtained was injected in deep dermal area using point by point and nappage technique. Patients have completed total of 4 sessions, at an interval of one month. Maintenance sessions were proposed 4 times per year. Mean hair count and hair thickness, global assessment by the investigators, subject self-assessment and adverse effects were assessed. Results: The mean number of hair follicles containing hairs per unit area improved at 3- and 6-months follow-up (p < .001), and all participants had a negative hair pull test. Hair volume and thickness, and patient-reported outcome scores also improved at follow-up (p < .001). Adverse effects were minor and self-limited. A series of three i-PRF injection sessions were effective for the treatment of FPHL, as shown by improved hair analysis parameters (in both V-scalp points and F-scalp points) and patient self-assessment scores. Conclusion: Injectable platelet rich fibrin (i-PRF) seems to be an effective therapy and safe autologous biomaterial for androgenetic alopecia . To ascertain and potentiate our findings, large scale studies are required.