摘要

Objectives: Describe the potential senolytic effects of topical acids in chemical peels, identify topical agents effective in reducing cellular senescence and improving mitochondrial health, and Identify AHA formulations that effectively counteract senescence with limited inflammation as outlined in recent research and data. Introduction: Senescence is a natural part of the cell cycle influenced by both genetic and epigenetic factors. Understanding cellular senescence and its role in the underlying mechanisms of aging is crucial for all aspects of medicine. Studies have shown that topical alpha hydroxy acids (AHA) may reduce senescence cells and senescence-associated secretory phenotype (SASP) and improve the overall mitochondrial health of the skin cells. Unfortunately, the inflammation associated with traditional chemical peels' high percentages and low pH may counteract these benefits. Materials / method: A search of PUBMED databases was performed to identify relevant literature published within the last five years, focusing on the potential senescence-controlling activity of topical alpha hydroxy acids (AHA). Additionally, we reviewed data highlighting findings for ideal parameters such as pH in peel efficacy, patient tolerance, and overall outcomes. Results: Even superficial chemical peels that utilize AHA have traditionally caused significant surface inflammation. While studies show a potential reduction in senescence and improvement in mitochondrial function, they must be used in appropriate formulations to achieve this benefit. Newer science indicates a potential link between regular acute inflammation--much like that associated with traditional chemical peels--and cellular senescence. Conclusion: Inflammation causes or exacerbates all cosmetic skin concerns. In addition, inflammation can lead to premature senescence and cellular damage. While inflammation was once our only option for creating change in the skin, science now offers new ways to work with the skin rather than against it, leveraging non-inflammatory, no-downtime AHA formulations.