摘要

Objectives: Understand the synergistic effects of combining vascular laser therapy with spicule-mediated peptide delivery in the treatment of post-acne erythema. Learn how micro-invasive peptide systems can enhance outcomes in inflammation-prone and sensitive skin types. Evaluate clinical tolerance, downtime, and efficacy compared to conventional monotherapies. Introduction: Post-acne erythema remains a common aesthetic concern, often persisting long after acne resolution, especially in sensitive or vascular-reactive skin. Vascular lasers such as pulsed-dye and long-pulsed Nd:YAG remain mainstays for targeting redness; however, their results can be inconsistent, and recurrence is common. Recently, interest has grown in combining energy-based treatments with biologically active systems that repair the skin barrier, modulate inflammation, and enhance dermal recovery. Materials / method: A micro-invasive peptide delivery system utilizing marine sponge-derived spicules was employed. The spicules were chemically bonded with anti-inflammatory peptides activated via glutathione. These were applied topically immediately following treatment with vascular lasers (e.g., Vbeam). Assessment metrics included: Reduction in erythema Patient-reported tolerance and downtime Improvement in skin texture and inflammatory lesion count Results: Patients who received the combination protocol exhibited: Faster reduction in post-acne erythema compared to laser-only treatment Improved tolerance with less reported dryness and pruritus due to barrier-supportive post-care Visible textural improvement and pore minimization, attributed to sustained peptide release over 72 hours Downtime was limited to mild erythema lasting <24 hours in most patients Conclusion: Combining vascular laser therapy with spicule-based peptide systems provides a powerful dual mechanism for resolving post-acne inflammation and enhancing skin quality. This protocol leverages the precision of laser targeting with the biological repair offered by extended peptide diffusion—offering a safe, non-injectable alternative for patients prioritizing minimal downtime and visible improvement.