Abstract

Objectives: explain the role of growth factors in hair growth and maintenace Options to treat different types of hair loss pathogenesis of hair loss explain the pathway in which growth factors work Introduction: The pathogenesis of hair loss is well defined; it is characterized by a decrease in hair synthesis and an increase in follicle breakdown, mediated by metalloproteinase’s. This net loss in hair volume and production is believed to contribute to and/or Alopecia. Biologic factors that are involved in wound healing might provide benefits for hair loss. Accordingly, growth factors, peptide fragments, and other biologically active molecules are being incorporated into anti-hair loss cosmeceuticals Materials / method: AQ hair complex product was used to evaluate 29 patients both males and females of different age groups. Periscope and photos were used to evaluate hair growth and distribution. We also used VISIA to measure hair count and microscope to measure hair width/thickness Results: 93% improvements were observed among all patients with 30% improvement on hair thickness. Conclusion: Growth factors are typically peptides with diverse biological effects. Some growth factor families that have been identified as useful in wound healing and/or epidermal remodeling include, e.g., transforming growth factor- ß (TGF- ß), epidermal growth factor, insulin-like growth factors (IGFs), platelet-derived growth factor (PDGF), and fibroblast growth factors (FGFs). This study corroborates the idea that the topical application of growth factors and cytokines are beneficial in reducing hair loss and promoting hair re-growth. Moreover, growth factors have been shown to restore hair growth.