Abstract

Objectives: To assess the effectiveness of using exosomes and botulinum toxin type A for treating large facial pores, facial flushing, and skin pigmentation. Introduction: Exosomes have recently received much attention for their effects on facial rejuvenation. The addition of exosomes to the intradermal injection of botulinum toxin was explored as a treatment protocol for skin conditions such as large skin pores, skin flushing, and skin pigmentation. Materials / method: Subjects with large facial pores, medium to severe skin flushing and skin pigmentation were separately selected for this study. These subjects were treated using the following sequence. On day 1, the subjects were treated via air dissection and micro-droplet Botulinum Toxin type A. After one week, exosome was applied to the treatment area using a meso-roller. Two weeks later, another round of air dissection and micro-droplet BTXA injection was followed by the exosome application the following week. The subjects were followed up 3 weeks and 6 weeks after the first treatment. Results: Visible improvements to pore size and depth, skin flushing, and skin pigmentation were first documented at 3 weeks after initial treatment. At 6 weeks after initial treatment, assessment using QuantifiCare 3D Lifeviz and Mark Vu facial skin analyzer showed a significant decrease in skin pores, improvement in skin flushing, and improvement in skin pigmentation. Conclusion: In this study, the use of exosomes and Botulinum Toxin type A has been demonstrated to be an effective protocol for the treatment of large facial pores, facial flushing, and skin pigmentation.