Abstract

Objectives: The aim of the study is to establish a protocol for the treatment and prevention of skin aging using combined techniques of peeling, a cocktail of biomimetic peptides vehicularized by microneedling and conventional biorevitalizing mesotherapy with non-cross-linked hyaluronic acid of high molecular weight (2700-3000)KDa in a single session. Introduction: The prevention and treatment of aging for each of the layers of the skin has led us to create the new concept of Mesosynergy, where we are going to offer each layer of the skin a personalized treatment covering the functional and morphological needs for which epidermis and dermis are characterized. The combined treatment was: a chemical peel in the epidermis, microneedling applied to the epidermis and superficial dermis, and injection of a non-cross-linked high molecular weight hyaluronic acid in the deep dermis. Materials / method: A combined peel whit composition is based in a modified Jessner formula (lactic acid 12.6 %, Citric acid 8.0% and Salicylic acid 2.0%) was performed in the facial area, prior to microneedling carried out with biomimetic peptides and it was finished by injecting 3.2 ml (HMWHA) distributed between the face and neck with 30G/4 mm needles in 11 volunteers of both sexes (8 female and 3 men). In total, 3 sessions once a month. Results: At the end of the treatment, an improvement in elasticity of 9.7%, an improvement in elastic recovery capacity of 10.6%, and a decrease in melanin of 5.4% compared to the baseline state, evidenced by the Cutometer® and Mexameter® probes, were evidenced. Conclusion: Despite the limited number of patients and the short follow-up time, the MESOSYNERGY protocol has demonstrated its effectiveness and safety for the treatment and prevention of aging.