Abstract

Objectives: When MSCs are delivered systemically, the majority of them become trapped in the lungs. Its survival, retention, and engraftment are limited in local applications. Their beneficial effects on cutaneous wounds are mostly mediated by paracrine activities. However, stem cell therapy may increase the risk of tumorigenesis and malformation. This is the message publicized on the website of US FDA. This is also why switching to exosomes may be the future of aesthetic dermatology. But, is exosome a promising rising star to replace stem cells in aesthetic dermatology? Introduction: Exosomes carries essential properties of MSCs, and are considered as an alternative to MSCs to avoid problems associated with cell-based therapy. Here are the overview of the composition of exosomes and the role of exosomes in medical aesthetics. They are wound healing, hair growth, anti-aging and hyperpigmentation. Conclusion: Cell-based and cell-free therapies will revolutionize the face of aesthetic dermatology. The application of exosomes has been given high expectations due to their convenience and safety in clinical practice. Despite promising preclinical data and small clinical studies, additional randomized, controlled trials and standardization of treatment are needed to truly understand the place of exosomes in the aesthetic arena. We hope regenerative medicine, especially exosomes will be a long-term alternative to restoring our skin’s native youthfulness and natural appearance without having to deal with