Abstract

Objectives: While a considerable number of cases with rosacea are resistant to conventional medications, therapeutic regimens are not currently established. Pu fractional microneedling radiofrequency (FMR) have previously demonstrated satisfactory results for anti-angiogenesis, anti-inflammation, and dermal remodeling and in addition to that we have added platelet rich plasma to the treatment to increase the efficacy of treatment Introduction: To evaluate the efficacy and safety of novel combination regimen with low-dose oral isotretinoin, PRP, and FMR in the treatment of recalcitrant Rosacea in patients with skin of color. Materials / method: A retrospective studies were undertaken for recalcitrant rosacea patients with skin of color to evaluate the clinical course of novel combination regimen. Case study of 5 patients has been discussed who has been treated successfully with the above regimen Results: And all patients achieved excellent improvement in the erythema of rosacea with long term maintainance of achieved results No serious side effect was observed during whole study periods Conclusion: This novel combination regimen demonstrated satisfactory efficacy with reasonable safety profiles for the treatment of recalcitrant rosacea in patients with skin of color