Abstract

Objectives: Skin aging and tissue aging represent significant concerns in dermatological and aesthetic medicine, driving the pursuit of effective biostimulation methods. Biostimulation involves the enhancement of dermal fibroblasts' anabolic functions, crucial for maintaining skin elasticity, strength, and the synthesis of vital extracellular matrix components such as collagen and elastin. This study aims to explore the efficacy of novel biostimulation inducers, with a focus on threads made from P(LA/CL)HA, in stimulating skin and tissue regeneration. Introduction: The primary objective of this research is to evaluate the skin and tissue stimulation effects of biostimulation threads, particularly those based on P(LA/CL)HA. This involves assessing their role in promoting collagen and elastin synthesis and their potential advantages over traditional materials like PDO, PLLA, PCL, and PLAGL. The study also aims to analyze existing literature to understand the broader context of tissue stimulation effects mediated by various thread materials. Materials / method: The study employed a comprehensive approach, including the analysis of publications describing tissue stimulation effects by threads based on different materials such as PDO, PLLA, PCL, PLAGL, and specifically P(LA/CL)HA. Pre-clinical studies were conducted to observe collagen types I and III stimulation, elastin fiber increase, and inflammatory response across different thread generations. Techniques included histological analysis and comparison of tissue reactions over a period of up to 180 days post-implantation. Results: Findings reveal a consistently high level of collagen I stimulation and a significant increase in collagen III and elastin fibers in tissues treated with P(LA/CL)HA threads. Notably, the new-generation threads demonstrated superior performance in elastin stimulation and reduced inflammatory responses compared to earlier generations and alternative materials. The analysis highlighted the threads' ability to induce a favorable extracellular matrix reaction, essential for effective biostimulation and tissue repair. Conclusion: The study confirms the positive role of P(LA/CL)HA-based threads in skin and tissue stimulation, showcasing their advanced biocompatibility, efficacy in promoting collagen and elastin synthesis, and reduced adverse reactions. These threads represent a promising advancement in aesthetic medicine, offering enhanced outcomes in skin rejuvenation and tissue repair. The comprehensive analysis of publications underlines the threads' superiority over traditional materials, pointing to their potential in revolutionizing biostimulation practices for improved skin health and aesthetics.