Abstract

Objectives: To evaluate the safety and efficacy of a topical depigmenting protocol in the management of clinically challenging hyperpigmentation cases. Introduction: Skin hyperpigmentation disorders—including melasma, post-inflammatory hyperpigmentation and solar lentigines—represent a growing global concern across all ethnicities and skin phototypes. Melasma and PIH are particularly challenging due to their multifactorial and complex pathophysiology, involving multiple cell types and signalling pathways. In aesthetic clinical practice, PIH is frequently observed as a consequence of sun exposure on skin sensitized by cosmetic procedures. Accurate diagnosis and a thorough understanding of available therapeutic options are essential for effective management Materials / method: 10 cases of melasma and post-inflammatory hyperpigmentation in male and female patients with Fitzpatrick phototypes I-V were treated using a targeted depigmenting protocol. Complex scenarios included PIH after chronic acne, aesthetic procedures such as chemical peels, IPL, or CO₂ laser or resistant melasma. The topical formulation combined retinol, diosmin, ferulic acid, and a novel chalcone-derived molecule for tyrosinase inhibition. Treatment started with clinical depigmenting and iontophoretic masks, followed by 120 days at home and periodic assessments with OBSERV 520x. Results: All patients demonstrated visible improvement in hyperpigmentation. Additionally, reductions in sebum production and enhancements in overall skin quality were observed, suggesting a broader restoration of skin homeostasis and function. Conclusion: This study demonstrates the efficacy and safety of an innovative depigmenting treatment in clinically challenging cases, highlighting its potential as a valuable tool in routine aesthetic clinical practice.