Objectives: There are possiblities of modern crosslinking of HA products without BDDE, which can influence human health after the use over decades. A new Key-Lock system of HA crosslinkage will be described and first study data in the use for Lip augmentation, NLF and Cheek augmentation will be shared

Introduction: The need to reduce the amount of BDDE in crosslinked HA is known for many years. Looking into the future use of HA we are expecting a use over decades in human beings, which could lead to health issues. So for an aesthetic physician using HA products routinely a product with no BDDE crosslinking is preferred in the long term use in our patients

Materials / method: In 3 different research centers a prospective study with a new HA formulation, crosslinked with no BDDE, but a key-lock system, was performed for the safety and efficacy for lip augmentation, NLF Augmentation and cheek enhancement. The amount of HA varied from 4 mg/ml (Lipaugmentation ) 6 mg /ml (NLF augmentation) 8 mg /ml (cheek enhancement). The followup was performed every 3 month until 12 month for the NLF and cheek group and 18 month for the lip augmentation group

Results: All three HA formulations showed good results with no safety issues over the study period. Despite the low amount of HA in all 3 formulations the results lasted longer as exspected.

Conclusion: The new KEY-LOCK crosslinking system for HA filler is a safe alternative to all BDDE crosslinked HA filler

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): Galderma

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability