Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Tranexamic acid is an antifibrinolytic indicated for severe bleeding with a dose between 2000 and 3000 mg.
Tranexamic acid inhibits the transformation of plasminogen into plasmin.
Plasmin promotes communication between the keratinocyte, melanocyte and fibroblast.
In this class we will discuss the mechanism of action of tranexamic acid, its indications for the treatment of Melasma, the tests necessary for its prescription, possible side effects and monitoring conduct.
Our goal is that after this class, the student can safely prescribe tranexamic acid for the treatment of Melasma.

Introduction: Melasma is a very prevalent, chronic dyschromia, with multifactorial etiopathogenesis characterized by brownish spots, preferably on the face of young women with a high skin type. Its etiology is multifactorial with the involvement of genetics, hormones, ultraviolet radiation and inflammation. Its treatment is a challenge for the dermatologist.
Tranexamic acid is an antifibrinolytic used to control intense bleeding that inhibits the transformation of plasminogen into plasmin.
Plasmin promotes the release of leukotrienes, stimulates the endothelial growth factor VEGF, favors the action of tyros

Materials / method: Studies are presented on the different actions of tranexamic acid for the treatment of Melasma. Furthermore, a meta-analysis was carried out at the University of Mogi das Cruzes with 32 studies of confirmed quality.

Results: After evaluating these various studies, we reached the following results:
Topical tranexamic acid can be used as an adjuvant in the treatment of Melasma. Its use has no side effects and helps with whitening. Systemic use is more effective when combined with hydroquinone than hydroquinone alone.
The use of oral Tranexamic must be supported by a complete history and necessary exams to avoid use in patients at risk of thrombosis.

Conclusion: The use of tranexamic acid in the treatment of Melasma is interesting to avoid provocative stimuli and can be used as an adjunct both at the beginning of treatment and for maintenance. More studies and scientifically based work are needed to establish definitive conclusions.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: demostrar que en la actualidad el melasma ,SI ES TRATRABLE, y que por muchos años se equivoco desde su forma de diagnosticarlo, por lo tanto de tratarlo y por eso , SI se equivocaba en la terapeutica ideal para esta patologia tan comun en la dermatologia latinoamericana.

Introduction: el melasma es una de las 5 patologias mas frecuentes de la consulta diaria dermatologica en latinoamerica, por lo cual es importante tener un concenso en la terapeutica del melasma.

Materials / method: se hace un concenso de los puntos importantes en la terapeutica del melasma, desde el punto de vista, topico, oral y con aparatologia ., dar su sitio acada uno de esto y su utilidad e indicacion real.

Results: presentar los antes y despues en pacientes de malasma en sus tres tipos ( pigmentario, vascular y mixto ), tanto su abordaje oral, topico y aparatologia.
para optimizar la terapia global en el melasma.

Conclusion: presentar un conceso de la terapeutica en el melasma en latinoamerica.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: To review literature on the topic since there is no a wide usage of metformine in this condition

Introduction: Melasma is a pigmentary disorder an chronic condition, with challenging treatments due to their adverse events or recalcitrant persistence of the disorder, and frequent relapsing after improvement.
We aim to seek evidence about literature covering this innovative treatment for melasma

Materials / method: Review of literature of recent articles on the topic

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Melasma is a common dermatosis that mainly affects the face of young women, with a huge emotional and cosmetic impact.
Photoprotection is a central part of the therapeutic strategy. The session aims to present the best photoprotection strategies for melasma

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability