Objectives: Skin aging and tissue aging represent significant concerns in dermatological and aesthetic medicine, driving the pursuit of effective biostimulation methods. Biostimulation involves the enhancement of dermal fibroblasts' anabolic functions, crucial for maintaining skin elasticity, strength, and the synthesis of vital extracellular matrix components such as collagen and elastin. This study aims to explore the efficacy of novel biostimulation inducers, with a focus on threads made from P(LA/CL)HA, in stimulating skin and tissue regeneration.

Introduction: The primary objective of this research is to evaluate the skin and tissue stimulation effects of biostimulation threads, particularly those based on P(LA/CL)HA. This involves assessing their role in promoting collagen and elastin synthesis and their potential advantages over traditional materials like PDO, PLLA, PCL, and PLAGL. The study also aims to analyze existing literature to understand the broader context of tissue stimulation effects mediated by various thread materials.

Materials / method: The study employed a comprehensive approach, including the analysis of publications describing tissue stimulation effects by threads based on different materials such as PDO, PLLA, PCL, PLAGL, and specifically P(LA/CL)HA. Pre-clinical studies were conducted to observe collagen types I and III stimulation, elastin fiber increase, and inflammatory response across different thread generations. Techniques included histological analysis and comparison of tissue reactions over a period of up to 180 days post-implantation.

Results: Findings reveal a consistently high level of collagen I stimulation and a significant increase in collagen III and elastin fibers in tissues treated with P(LA/CL)HA threads. Notably, the new-generation threads demonstrated superior performance in elastin stimulation and reduced inflammatory responses compared to earlier generations and alternative materials. The analysis highlighted the threads' ability to induce a favorable extracellular matrix reaction, essential for effective biostimulation and tissue repair.

Conclusion: The study confirms the positive role of P(LA/CL)HA-based threads in skin and tissue stimulation, showcasing their advanced biocompatibility, efficacy in promoting collagen and elastin synthesis, and reduced adverse reactions. These threads represent a promising advancement in aesthetic medicine, offering enhanced outcomes in skin rejuvenation and tissue repair. The comprehensive analysis of publications underlines the threads' superiority over traditional materials, pointing to their potential in revolutionizing biostimulation practices for improved skin health and aesthetics.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: The design for thread lifting could enhance facial widening and prominent cheek bone with is not a preferable outcome in Asian. Here, I will show my design and technique on VDO demonstration to avoid prominent zygoma and maximize lifting effect to create nice outcome for Asian face.

Objectives: Patients with facial paresis suffer by limited tissue function and noticeable facial asymmetry. We use combination of threads as a treatment. The outcomes demonstrate enhanced facial symmetry, improved support for limited tissue function, and a subjectively elevated quality of life for patients.

Introduction: Facial paresis is often caused by oncological diseases that require surgical intervention. However, this can result in damage to the facial nerve, leading to limited tissue function and visible signs of facial asymmetry.

Materials / method: We have focused on using thread lifting as a minimally invasive intervention for patients with facial paresis. This treatment is performed under local anesthesia, which is beneficial for patients who have undergone multiple surgeries under general anesthesia in the past. Thread lifting is considered a safe and effective method, utilizing various types of threads, absorbable and non-absorbable, specifically for these cases.

Results: Barbed threads are used to lift tissue in ptosis and restore lost volume in the cheekbone area. We can also rebuild the disappeared nasolabial fold, helping to achieve facial symmetry.

Conclusion: The use of absorbable and non-absorbable threads in the treatment of facial paresis can yield valuable results. This minimally invasive method offers a less traumatic procedure under local anesthesia, with a relatively fast recovery time. The results show improved facial symmetry, support for limited tissue function, and a subjectively higher quality of life for patients.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability