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IMCAS Asia 2025
Program

Breast implant challenging outcomes: how to solve them (in collaboration with MSPRS)

Partner of the session

MSPRS

Malaysian Society of Plastic and Reconstructive Surgery

Malaysia

Room: Room 5 - Level 2
Date: Friday 6 June 2025 at 14:00 to 15:00
Format: FOCUS SESSION > lectures covering a major topic of the congress

Chairs

Dr Nimrod FRIEDMAN

Plastic Surgeon

Israel

Dr Shah Jumaat MOHD YUSSOF

Plastic Surgeon

Malaysia

Lectures of the session

Hours	Speakers	Lecture title	Abstract	Number
14:00	Dr Shamala DURAIRAJANAYAGAM	Driainless closure of extended latissimus dorsi flap donor site using only quilting sutures		146748
14:12	Dr Hanna LUZE	Autologous vs. alloplastic breast reconstruction – Differences in complication rates and long-term satisfaction	View	146747
14:24	Dr Frank LISTA	Breast implant sizing: key to the happy patient		146749
14:36	Dr Shin Hyuk KANG	TNF-α-treated ADSCs enhance inherent radiation tolerance and alleviate breast implant capsular contracture	View	146750
14:48		Discussion and Q&A		146751

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Breast cancer & reconstruction

Breast augmentation

Breast implant

Adipose tissue

Growth factors

Dr Shamala DURAIRAJANAYAGAM

Plastic Surgeon

Malaysia

Other author(s) :

Driainless closure of extended latissimus dorsi flap donor site using only quilting sutures

Dr Hanna LUZE

Plastic Surgeon

Austria

Other author(s) : Thomas Rappl, Sebastian P. Nischwitu

Autologous vs. alloplastic breast reconstruction – Differences in complication rates and long-term satisfaction

Objectives: High oncological safety as well as patient satisfaction regarding the aesthetic-functional result is of utmost importance in modern breast cancer management.
This study focuses on long term outcomes as well as patient-reported outcome in different breast reconstruction techniques. Data from this study is essential in offering an optimized, individual treatment plan.

Introduction: For breast reconstruction after mastectomy, alloplastic alternatives with silicone implants are available in addition to various autologous reconstruction options such as free flaps or autologous fat grafting. Previous studies have focused on the possible complications of the techniques in detail, but there have been no conclusive comparative studies to date. In addition, existing data from isolated studies on the quality of life, satisfaction, psychosocial and physical well-being of patients who underwent breast reconstruction after breast cancer is inconclusive and not comparable.

Materials / method: In the course of a multicenter retrospective data analysis, complication types and rates as well as several other patient- and surgery related factors were evaluated in free tissue transfer (deep inferior epigastric artery perforator flap, transverse rectus abdominis myocutaneous flap, or latissimus flap), and the use of implants or tissue expanders for breast reconstruction after carcinoma therapy. Standardized Breast-Q questionnaires were used to analyze quality of life, satisfaction, psychosocial and physical well-being in different techniques.

Results: Within the study collective, significant differences regarding the complication types and rates were found and will be discussed together with the results of the current literature. Despite higher complication rates and number of revision surgeries, the long-term satisfaction was shown to be significantly higher in patients who underwent autologous breast reconstruction.

Conclusion: Significant differences in complication types and rates as well as long-term satisfaction were shown in different reconstruction techniques. Findings of these study may aid in preoperative decision-making along with patient-related factors, in order to generate the best result for each patient individually.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Dr Frank LISTA

Plastic Surgeon

Canada

Other author(s) :

Breast implant sizing: key to the happy patient

Dr Shin Hyuk KANG

Plastic Surgeon

South Korea

Other author(s) : Tae Hyung Kim, Ji Hoon Kim, Noori Park, Hansoo Park, Shin Hyuk Kang

TNF-α-treated ADSCs enhance inherent radiation tolerance and alleviate breast implant capsular contracture

Objectives: This study investigates the potential of TNF-a-treated human ADSCs on silicone implants to alleviate RICC, hypothesizing to enhance suppressive effects on radiation-induced capsular contracture(RICC) by modulating inflammatory responses in a radiation-exposed environment.

Introduction: Post-mastectomy radiotherapy plays a crucial role in breast cancer treatment but can lead to an inflammatory response causing soft tissue damage, particularly radiation-induced capsular contracture (RICC), impacting breast reconstruction outcomes. Adipose-derived stem cells (ADSCs), known for their regenerative potential via paracrine capacity, exhibit inherent radiotolerance. The influence of tumor necrosis factor-alpha (TNF-a) on ADSCs has been reported to enhance the paracrine effect of ADSCs, promoting wound healing by modulating inflammatory responses.

Materials / method: In vitro, T-hASCs were cultured on various surfaces to assess viability after exposure to radiation up to 20 Gy. In vivo, T-hASC and non-TNF-a-treated hASC (C-hASCs)-coated membranes werevimplanted in mice before radiation exposure, and an evaluation of the RICC mitigation took place 4 and 8 weeks after implantation. In addition, the growth factors released from T-hASCs were assessed.

Results: In vitro, hASCs displayed significant radiotolerance, maintaining consistent viability after exposure to 10 Gy. TNF-a treatment further enhanced radiation tolerance, as evidenced by significantly higher viability than C-hASCs at 20 Gy. In vivo, T-hASC-coated implants effectively suppressed RICC, reducing capsule thickness. T-hASCs exhibited remarkable modulation of the inflammatory response, suppressing M1 macrophage polarization while enhancing M2 polarization. The elevated secretion of vascular endothelial growth factor from T-hASCs is believed to induce macrophage polarization.

Conclusion: This study establishes T-hASCs as a promising strategy for ameliorating the adverse effects experienced by breast reconstruction patients after mastectomy and radiation therapy. The observed radiotolerance, anti-fibrotic effects, and immune modulation suggest the possibility of enhancing patient outcomes and quality of life. Further research and clinical trials are warranted for broader clinical uses.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Discussion and Q&A

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IMCAS Asia 2025 Program

Breast implant challenging outcomes: how to solve them (in collaboration with MSPRS)

Chairs

Lectures of the session

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IMCAS Asia 2025
Program