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IMCAS Asia 2025
Program

NON-SPONSORED SCIENTIFIC E-POSTERS

Room: E-Poster Area
Format: OPEN STAGE LIBRARY > digital library of e-posters displayed during the whole conference period

Speakers	Lecture title	Abstract	Number
Dr Anood AL ISSA	Safety First: Critical Insights into the Clean Beauty Ingredient Movement	View	145558
Dr Anood AL ISSA	Exosomes in Dermatology: Bridging the Gap Between Hype & Hope	View	145559
Dr Anood AL ISSA	From Genetics to Growth: Novel Approaches to Androgenic Alopecia	View	145560
Dr Christelle GUILLON	Retention of Broken Cannula Tip Following Debulking of Lower Limb Free Flap Reconstruction: Rare Case Report and Literature Review	View	148587
Dr Keita TAKANASHI	Anti-aging mechanism of skin cells through macrophage activation by brown rice extract	View	148382
Dr Rey Tristan Joshua UNAY	A Kaleidoscope of Skin: Incontinentia Pigmenti in a Newborn	View	145591
Dr Chahat VERMA	Five component composite augmentation spreader grafts in Rhinoplasty	View	148136
Dr Yuanyuan WANG	Clinical Experience of Primary Subcutaneous Mycoses in Shanghai: A Retrospective Analysis	View	148423
Dr Yuanyuan WANG	A rare case of skin infection caused by Corynebacterium striatum in an immunocompromised adult	View	148497
Dr Chadakan YAN	Comparative Effectiveness and Safety of Fractional Laser and Fractional Radiofrequency for Atrophic Acne Scars A Propensity Score Analysis	View	149026

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Recommended sessions

Skin diseases

Scars

Dermatologic surgery

Nose (rhinoplasty - surgical)

Alopecia (hair loss)

Dr Anood AL ISSA

Dermatologist

Jordan

Other author(s) :

Safety First: Critical Insights into the Clean Beauty Ingredient Movement

Objectives: Evaluate Scientific Evidence: Assess the validity of claims made by clean beauty products regarding ingredient safety.
Identify Key Risks: Examine the potential dangers of commonly avoided ingredients, such as irritants, endocrine disruptors, and carcinogens.
Clarify Regulatory Oversight: Explore the impact of existing cosmetic regulations on ingredient safety and consumer protection.
Provide Evidence-Based Guidance: Offer clear, research-backed recommendations for navigating clean beauty products effectively.

Introduction: Clean beauty products dominate the market, offering promises of safety and purity. However, their claims often lack robust scientific validation. This research examines the potential risks of ingredients flagged by the clean beauty movement, addressing concerns over allergens, hormonal disruptors, and carcinogens, to uncover the reality behind the marketing.

Materials / method: This study investigates clean beauty ingredient safety through a comprehensive literature review. Key databases such as PubMed, MEDLINE, and Embase were systematically searched using targeted Medical Subject Headings (MeSH) and keywords. Peer-reviewed articles, clinical trials, and reviews were meticulously selected for their relevance and recent publication dates. Data extraction and synthesis focused on evaluating the scientific evidence behind commonly scrutinized ingredients, ensuring a rigorous analysis of their safety profiles.

Results: Irritants: MI, fragrance, and formaldehyde are confirmed allergens linked to dermatitis, validating their exclusion in clean beauty.
Endocrine Disruptors: The link between chemicals like Triclosan and hormonal disruption remains uncertain, with most studies conducted on animals.
Carcinogens: Formaldehyde and 1,4-dioxane are associated with cancer risk, though evidence is still emerging.
Overall: Clean beauty promotes scrutiny of ingredients, but more research is needed to fully validate the safety of many claims.

Conclusion: The clean beauty movement has highlighted the importance of scrutinizing cosmetic ingredients, revealing that some commonly avoided chemicals, like MI, fragrance, and formaldehyde, are linked to known health issues. However, the safety of many other "clean" ingredients remains inconclusive, with limited human studies. While eliminating certain harmful ingredients is prudent, more research is needed to fully understand the effects of many "clean" cosmetics components on human health.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Dr Anood AL ISSA

Dermatologist

Jordan

Other author(s) :

Exosomes in Dermatology: Bridging the Gap Between Hype & Hope

Objectives: -Understand exosomes' role in intercellular communication and their promise for skin regeneration and wound healing
-Evaluate exosomes as innovative treatments for inflammatory and autoimmune skin conditions
-Identify challenges such as standardization issues, preclinical model limitations, and the need for comprehensive safety evaluations
-Focus on improving exosome purification, understanding their diversity, and establishing robust regulatory frameworks
-Stress the importance of rigorous clinical validation and enhanced regulatory oversight to fully realize exosome potential in dermatology

Introduction: Exosomes, nanoscale vesicles (30–150 nm) with a lipid bilayer,have emerged as crucial elements in dermatology due to their role in intercellular signaling &their potential as cell-free therapeutics.Rich in proteins, lipids& nucleic acids, these vesicles retain the biological properties of their source cells and offer promising advancements in skin regeneration,wound healing &management of inflammatory & autoimmune skin disorders.Recent research underscores their ability to bridge medical &cosmetic dermatology,highlighting the need for further exploration to unlock their full clinical potential

Materials / method: Literature Review: Reviewed peer-reviewed articles in dermatology from PubMed, Google Scholar, and Scopus.
Content Analysis: Analyzed dermatology content from PubMed, ResearchGate, Google Scholar, and professional dermatology forums, categorizing it and assessing engagement with analytics tools.

Results: Exosomes in dermatology show promise for skin regeneration, wound healing, and managing inflammatory and autoimmune conditions. They enhance scar treatment, promote hair growth, and aid in wound recovery. Derived from sources like stem cells and dermal papillae, they improve skin conditions and reduce scarring. However, challenges in isolation standardization and long-term safety need addressing. Despite these hurdles, ongoing research suggests that exosomes could revolutionize dermatological treatments with their unique therapeutic capabilities.

Conclusion: Exosomes are revolutionizing dermatology, bridging the gap between potential and application. They play a significant role in skin regeneration, wound healing, and treating inflammatory and autoimmune skin diseases. Stem cell-derived exosomes offer innovative solutions with reduced risk compared to direct stem cell therapies. However, challenges in purification, standardization, and regulation remain. Future research must address these issues to fully realize exosomes' therapeutic potential and ensure their safe clinical use.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Dr Anood AL ISSA

Dermatologist

Jordan

Other author(s) :

From Genetics to Growth: Novel Approaches to Androgenic Alopecia

Objectives: - Decoding Patterns: Distinguish the clinical presentations of Androgenic Alopecia (AGA) in both men and women.
- Hormonal and Genetic Blueprint: Delve into the genetic predispositions and hormonal influences underlying AGA.
- Therapeutic Landscape: Explore established FDA-approved treatments, off-label options, and groundbreaking innovations.
- Advanced Care Approaches: Assess the efficacy of combined and cutting-edge therapeutic strategies.
- Future Horizons: Investigate emerging research and novel interventions shaping AGA management.

Introduction: As the most prevalent cause of hair loss, Androgenic Alopecia (AGA) affects men and women differently but shares a foundation in genetic susceptibility and hormonal imbalances. Dihydrotestosterone (DHT) drives follicular miniaturization, with links to cardiovascular risks in men and polycystic ovarian syndrome (PCOS) in women. Despite its ubiquity, therapeutic advancements have lagged, with limited FDA-approved options. This presentation examines the evolving therapeutic paradigm, spotlighting innovative and synergistic approaches to elevate clinical outcomes in AGA management.

Materials / method: A thorough review of scientific literature was conducted across databases including Medline, PubMed, Embase, and EBSCO, supplemented by authoritative dermatology texts. The findings were further enriched by the clinical experience of seasoned practitioners and key insights into AGA management trends. This comprehensive analysis underpins the strategies detailed in this study.

Results: - FDA-Approved Essentials: Minoxidil and finasteride lead AGA management, complemented by the LaserMax HairComb as the sole FDA-approved device.
- Innovative Frontiers: Emerging therapies like LLLT, microneedling, PRP, oral and topical finasteride, spironolactone, botulinum toxin, and stem cell treatments offer transformative potential.
- Hair Transplantation: Aesthetic success demands ongoing maintenance to sustain results.
- Research Gaps: Advancements hinge on large-scale, rigorous trials to solidify efficacy and safety.

Conclusion: While minoxidil, finasteride, and the LaserMax HairComb form the backbone of AGA treatment, their inconsistent outcomes and side effect profiles highlight the need for alternatives. Innovative approaches like LLLT, PRP, microneedling, and stem cell treatments offer hope but demand further validation. Hair transplantation enhances aesthetics but falls short in halting progression. To transform AGA care, large-scale, comparative, and placebo-controlled trials are essential to establish reliable and effective treatment standards.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Dr Christelle GUILLON

Plastic Surgeon

Singapore

Other author(s) : O-Wern Low, Vigneswaran Nallathamby

Retention of Broken Cannula Tip Following Debulking of Lower Limb Free Flap Reconstruction: Rare Case Report and Literature Review

Objectives: Liposuction has become a a highly common procedure performed by plastic surgeons since its advent in 1979. However, it is not without risk. The authors report their experience with breakage and retention of the tip of a liposuction infiltration cannula. They also discuss their implemented interventions to prevent recurrence of such complications.

Introduction: Liposuction is a common cosmetic and functional procedure. It is generally considered safe. The most common complications are seroma, haematoma, and bruising. Breakage of the tip of the cannula has rarely been reported in literature. The authors report their experience with retention of a broken tip of an infiltration cannula, their subsequent management, and learning points.

Materials / method: A 66-year-old man with previous anterolateral thigh (ALT) free flap reconstruction for his right foot underwent liposuction-assisted and open surgical debulking of the flap. Over the next 2 weeks, the proximal third of the flap developed full thickness necrosis, wound dehiscence, and purulent discharge. Bedside debridement revealed an 18-mm cannula tip lodged in the subcutaneous tissue. This led to full disclosure, intravenous antibiotics, and formal surgical debridement in the operating theatre. He eventually received skin graft coverage over the new wound.

Results: Late recontouring of bulky cutaneous flaps using liposuction is common, particularly in lower limb reconstruction, for achieving well-contoured coverage. In our case, an infiltration cannula tip broke intra-operatively, marking the first reported instance during lower limb flap debulking. Factors such as instrument wear, suboptimal technique, and the tip's small size may have contributed to this. Interventions include purchase of a new liposuction set, replacement of the broken cannula, phasing out cannula calibre < 2-mm, and new protocols for measurement of cannulas before and after use.

Conclusion: The authors’ experience, together with the cited case reports, demonstrate that cannula tip breakage (be it during infiltration or liposuction) is rare but possible. Surgeons should be cognisant of these risks and counsel patients appropriately. They should also select appropriate instruments for their task and ensure good technique. OT staff may also put in place stricter protocols for inspection and maintenance of instruments. All team members handling the instruments should carefully inspect them before and after use, particularly the fragile points.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Dr Keita TAKANASHI

PhD - Research

Japan

Other author(s) : Katsuaki Dan, Tatsuo Shinozuka, Kenji Watanabe, Yu Jing, Koji Tomobe

Anti-aging mechanism of skin cells through macrophage activation by brown rice extract

Objectives: In this study, we investigated whether the mature extract of brown rice (KR-ex.), which is made by extracting only the nutritious parts of brown rice (sub-aleurone layer, scutellum of germ, and crushed cell group), exerts an anti-aging effect on skin fibroblasts through the activation of human macrophages (MΦ). That is, we aimed to pursue the anti-aging effect of skin through inner care by gene expression of fibroblast proliferation-promoting growth factor 2 (FGF2) and STAB1, which is necessary for phagocytosis of aged fibroblasts, when cultured human MΦ are stimulated with KR-ex.

Introduction: In Japan, KR-ex. has been commercialized as a functional food. It has been reported that it has health benefits such as reduced susceptibility to colds and a decrease in the prevalence of skin problems. We have clarified the immune-stimulating effect of KR-ex. by activating human MΦ in an in vitro system and shifting intracellular energy metabolism from mitochondria to glycolysis. However, the effects of KR-ex. on the skin remain unclear. In recent years, the relationship between the M1/M2 balance and the dysregulation of collagen homeostasis in photoaged skin has been demonstrated.

Materials / method: KR-ex. was added to MΦ-like cells differentiated from human monocyte cell line (U937 cells) with phorbol myristate acetate and allowed to act for 24 hours. In addition, a control (Cntrl) was prepared by adding sterilized purified water, and a positive control was prepared by adding lipopolysaccharide (LPS) (1 μg/mL). Macrophage activation was measured by gene (mRNA) expression of interleukin (IL)-1β (M1 type) and STAB1 (M2 type), which are produced during MΦ activation. The mRNA expression of growth factor (FGF2), which directly activates fibroblasts, was also measured.

Results: The expression of STAB1 in MΦ treated with KR-ex. decreased in a KR-ex. concentration-dependent manner and showed a negative correlation with IL-1β. Meanwhile, FGF2 was generally expressed at a low level, but was significantly higher than that of Cntrl at 10 μg/mL and 100 μg/mL or more. Overall, changes in the behavior of gene expression were observed at 33.3 μg/mL and 100 μg/mL, which are the intermediate concentrations of the six KR-ex. concentrations. At low concentrations, only M2Φ-related genes were expressed, while at high concentrations, both M1Φ- and M2Φ-related genes were expressed.

Conclusion: It was suggested that KR-ex. may promote the proliferation of skin fibroblasts through growth factors such as FGF2 via the activation of MΦ, and that the enhanced phagocytic ability due to STAB1 expression may exert an anti-aging effect on skin tissue by eliminating senescent fibroblasts. KR-ex. is a functional food that may have an effect on improving skin, and is also thought to expand the possibilities for cosmetics that can contribute to skin aging.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Dr Rey Tristan Joshua UNAY

Dermatologist

Philippines

Other author(s) : Rainier D. Galutera, MD, FPDS, Judith V. Parungao, MD, DPDS, Jolene Kristine G. Dumlao, MD, FPDS, FDSP-PDS

A Kaleidoscope of Skin: Incontinentia Pigmenti in a Newborn

Objectives: To describe a rare case of Incontinentia Pigmenti (IP) in a newborn Filipino female patient.
To highlight the clinical manifestations and diagnostic challenges associated with IP in early infancy.
To emphasize the importance of early recognition and management of IP to prevent potential complications.
To contribute to the limited literature on IP in the Filipino population.

Introduction: Incontinentia Pigmenti (IP) is a rare X-linked dominant genodermatosis characterized by a distinctive pattern of skin lesions that progress through four stages. This case report presents a rare case of IP in a newborn Filipino female patient, highlighting the importance of early recognition and management of this complex condition.

Materials / method: We reported a case of a 1-day-old female neonate with multiple vesicles, pustules, and desquamated patches on erythematous plaques on her scalp, trunk, buttocks, genitals, and extremities. Dermoscopic examination for new vesicles revealed a yellow center and erythematous halo, while older lesions had yellowish serocrusts surrounded by scaling.

Results: Tzanck smear showed multiple eosinophils, and punch biopsy of one of the lesions revealed eosinophilic spongiotic dermatitis, consistent with IP. The patient's eye exam was normal, and she had occasional seizures that were managed with medication. Upon discharge, her eye exam was still normal, and she was seizure-free. She was treated with emollients and topical steroids to help manage her intermittent skin flares with favorable results.

Conclusion: This case report highlights the importance of early diagnosis and treatment of IP. The skin lesions can be very distinctive, but they can also be less obvious, especially to non-dermatologists. Raising awareness of IP will help to prevent unnecessary medical interventions and ensure that patients receive the care they need. Patient and family education about the genetic implications of IP and its other potential complications is also imperative.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Dr Chahat VERMA

Plastic Surgeon

India

Other author(s) :

Five component composite augmentation spreader grafts in Rhinoplasty

Objectives: To study the aesthetic outcomes of dorsal augmentation by five components composite L - strut Autogenous rib cartilagenous framework fixed to nasal bone by grooving.

Introduction: Aesthetic and functional problems are encountered due to collapse of nasal dorsum that can be due to infection, post traumatic, congenital or iatrogenic causes. Dorsal augmentation via costal cartilage is a valuable means of improving nasal appearance by correcting low and/or concave nasal dorsum.
Various options for autologous augmentation of nasal dorsum include - Diced Cartilage Fascia (DCF), solid rib cartilage, sliced counter opposed rib cartilage etc. Costal cartilage provides reliable structural support with sufficient strength, resistance to resorption and is present in good quantity.

Materials / method: The framework is reconstructed into five components: The strips are cut 1.5-3mm thick, 3.5- 4 cm long, and 6-7mm wide for spreader/septal augmentation. Caudal strips which are 1.5-2mm thick, 20-25 mm long and 4-5mm wide and at its posterior end, wedge is made for the Anterior Nasal Spine. The caudal and dorsal strips are sutured tongue in a groove fashion at the desired angle. A Gap graft is placed. DCF- For dorsal onlay placed. A groove is made in the nasal bone on either side up to the Bony Radix. The groove is made just of adequate width to fit the cartilage snugly.

Results: Out of 15 cases (9 females and 6 males), 7 were Binder’s syndrome and 8 were of severe saddle nose deformity. No major complications were seen like graft warping, skin necrosis, infection, except in one patient who had slight hump on one side of nose because of DCF mal-alignment. All patients were satisfied with the aesthetic outcome with mean follow up of 11 months. None of the patients complained of airway problems postoperatively.

Conclusion: Our study shows that it is an instrumental technique for Indian patients with thick nasal skin. Our technique uses the advantage of both the solid structural augmentation and soft dorsum for good contour and no graft show. Internal nasal valve collapse is prevented and there is significant improvement in patient’s functionality.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Dr Yuanyuan WANG

China

Other author(s) : Qian Yu， Wei Li

Clinical Experience of Primary Subcutaneous Mycoses in Shanghai: A Retrospective Analysis

Objectives: The nonspecific clinical symptoms of primary subcutaneous mycoses pose significant challenges for clinicians. Increased awareness of these infections can help prevent adverse outcomes associated with delayed diagnosis and treatment. Therefore, a study that focuses on primary subcutaneous mycoses in Shanghai and summarizes the clinical experience is warranted.We summarized the clinical features, histopathological findings, etiological characteristics, drug sensitivity test results, therapeutic regimens, and follow-up data to optimize the management of subcutaneous mycoses in Shanghai.

Introduction: Primary subcutaneous mycoses are a heterogeneous group of fungal infections caused by pathogenic or opportunistic organisms. In recent years, cases have steadily increased in Shanghai, an area where the disease was previously uncommon. This study aimed to summarize clinical experiences with primary subcutaneous mycoses in Shanghai, to optimize their management.

Materials / method: 33 patients with confirmed primary subcutaneous mycoses were enrolled . Their medical histories, clinical features, histopathological findings, etiological characteristics, drug sensitivity tests, therapeutic regimens, and follow-up data were recorded.

Results: Identification of pathogens from skin tissue cultures revealed distinct colonial morphologies across diverse mycological species. The isolates included yeast (45.5%), mold (30.3%), and dimorphic fungi (24.2%). The most common species were C. parapsilosis (n = 8, 24.2%), T. rubrum (n = 5, 15.2%), and S. schenckii (n = 8, 24.2%). Thirty-two patients received systemic antifungal treatment based on the results of the drug sensitivity test, whereas one patient was treated with complete surgical resection, owing to a single plaque.

Conclusion: This study highlights the considerable diversity among fungal species implicated in primary cutaneous mycoses and underscores the complexities involved in their accurate diagnosis and management. Correcting unhealthy lifestyles, boosting immunity, and completely removing and avoiding re-exposure to the pathogenic fungi can effectively reduce the risk of relapse in primary subcutaneous mycoses. Our findings provide valuable insights into primary subcutaneous mycoses and may contribute to improved patient prognoses.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Dr Yuanyuan WANG

China

Other author(s) : Qian Yu， Wei Li

A rare case of skin infection caused by Corynebacterium striatum in an immunocompromised adult

Objectives: C. striatum has significantly challenged the healthcare of adults, especially those with weakened immune systems. However, skin infections are occasionally associated with C. striatum and such cases were rarely described. This report presents a rare case of skin infection caused by multidrugresistant C. striatum in a patient with prior medical history of rheumatoid.

Introduction: Corynebacterium striatum (C. striatum) is commonly viewed as a contaminant once isolated from clinical specimens as it often colonizes human skin and mucous membranes. As an emerging causative agent of hospital-acquired infections, C. striatum has increasingly associated with various infections in immunocompromised and hospitalized patients, particularly in rising cases of drug-resistant and multidrug-resistant infections. However, skin infections are occasionally associated with C. striatum and such cases have been infrequently documented.

Materials / method: This is a Case report.Here we report a rare case of a 62-year-old female with prior medical history of rheumatoid arthritis and breast cancer, who experienced a non-healing skin abscess on her right hand for one year following an accidental cut.

Results: Cultures obtained from both pus and deep subcutaneous tissue produced non-hemolytic and milky-white colonies when grown on 5% sheep’s blood agar. The isolate was promptly identified as C. striatum using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Based on the in vitro antimicrobial susceptibility testing results, the lesion was effectively treated with a combination of rifampicin and clarithromycin over a period of 3 months.

Conclusion: This case highlights the risk factors for C. striatum and the potential of C. striatum as a possible pathogen causing skin infection, rather than merely a clinical contaminant.We recommend that all pure cultures of diphtheroids be identified to the species level, and their antimicrobial susceptibility testing be conducted to facilitate the initiation of prompt and appropriate treatment for a successful outcome.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Dr Chadakan YAN

Thailand

Other author(s) : Chadakan Yan, M.D. MBA. , Phichayut Phinyo, M.D., M.Sc., Ph.D., Yuri Yogya, M.D., Mati Chuamanochan, M.D., Rungsima Wanitphakdeedecha, M.D., M.A., M.Sc., Ph.D.

Comparative Effectiveness and Safety of Fractional Laser and Fractional Radiofrequency for Atrophic Acne Scars A Propensity Score Analysis

Objectives: To compare the clinical effectiveness and safety of fL and fRF in the treatment of atrophic acne scars.

Introduction: Atrophic acne scars are a common dermatologic concern, particularly in Asian populations where the risk of post-inflammatory hyperpigmentation (PIH) is elevated. Fractional laser (fL) and fractional radiofrequency (fRF) are widely used energy-based devices (EBDs), but comparative evidence in Fitzpatrick skin types III–IV remains limited.

Materials / method: A retrospective cohort study was conducted among patients aged 18–60 years who underwent at least two sessions of fL or fRF between 2012 and 2023. Propensity score (PS) stratification adjusted for baseline confounders. Clinical improvement was assessed at 1, 3, and 6 months. Missing data were handled via multiple imputation. The primary outcome was the proportion of patients achieving ≥25% improvement. Equivalence testing was performed with a predefined margin of 20%.

Results: A total of 397 patients were included (254 fL; 143 fRF). After PS stratification, baseline characteristics were balanced. At 6 months, ≥25% improvement was achieved in 88.1% of fRF-treated and 71.9% of fL-treated patients. While fRF consistently showed greater mean improvement, differences were not statistically significant. fL was not inferior to fRF. Pain scores were significantly higher with fRF (p < 0.001), but adverse events, including PIH, were infrequent and comparable.

Conclusion: Both fL and fRF are effective and safe for treating atrophic acne scars in Fitzpatrick skin types III–IV. fL was not inferior to fRF while fRF showed more discomfort but comparable safety.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

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