Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Understanding the technique of using autologous costal cartilage for dorsal onlay graft and its clinical outcomes.

Introduction: In conventional rhinoplasty, silicone is used for dorsal augmentation along with tip plasty. However, complications such as inflammation or deformation can occur due to silicone implants. In such cases, autologous grafts are employed for dorsal augmentation, with rib cartilage being a good option.

Materials / method: To perform a dorsal onlay graft using autologous costal cartilage, an adequate amount of rib cartilage is required. Typically, the seventh rib cartilage is preferred due to its length and thickness. The entire seventh costal cartilage is harvested, and the straightest portion is designed into a boat shape similar to a silicone implant. The cartilage is then cut and carved to the desired shape with the appropriate thickness.

Results: Good surgical outcomes were achieved using only autologous tissue in cases of contracted or deformed noses.

Conclusion: Dorsal augmentation using autologous costal cartilage can be a good alternative for contracted or deformed noses.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: This research focuses on a biologically active, regenerative alternative for sustained periorbital rejuvenation.
1. Evaluate the Efficacy of ACF Filler
2. Comparison with other autologous-derived materials (such as Coleman fat, nanofat, and ACF).
3. Analyze Patient Satisfaction and Clinical Outcomes
4. Investigate the Regenerative and Biostimulatory Potential of ACF
5. Ensure Safety and Minimize Complications
6. Validate ACF as a Long-Lasting Alternative to Traditional Fillers
7. What to bring from Autologous-Derived Materials to the Future of Regenerative Biomaterials

Introduction: Infraorbital dark circles are a prevalent aesthetic concern worldwide​. This condition arises from anatomical and physiological factors​. The periorbital skin is among the thinnest in the body and, with age-related collagen loss, becomes increasingly translucent—revealing the underlying vascular​. Concurrently, atrophy of periorbital fat pads and surrounding support structures leads to depression and shadowing​. By correcting root structural causes rather than merely masking symptoms, these approaches offer the potential for more resolution of infraorbital dark circles​.

Materials / method: For Animal Study:
Characterization Methods: Histology, Immunostaining, Western blotting, cell viability assays.
Proteomic Analysis: Evaluation of bioactive components in ACF.
Evaluations：Collagen synthesis/degradation, Skin barrier function, Skin filling effectiveness, Collagen remodeling process, dermal thickness, fibroblast expression, antioxidase expression
For Clinical Study: Subjects with dark circles.
Intervention: Single session of Intradermal ACF injection with 8 months follow-up.
Outcome measures: Clinical improvement assessed via Global Aesthetic Improvement Scale (GAIS)

Results: 1. Patient satisfaction:
86% reported being "highly satisfied" or "satisfied." Improvements included brighter, tighter, and smoother infraorbital skin.
2. Clinical outcome (GAIS evaluation):
Over 97% rated as "improved,or above by three independent surgeons. No irregularities or lumps observed during follow-up.
3. ACF-derived adipokines contained anti-inflammatory, skin barrier- and lipidbiosynthesis-related components. ACF contained nonviable cells and high levels of collagen I, collagen IV, and laminin. Fibroblasts and procollagen significantly increased in ACF.

Conclusion: ACF filler is an innovative intradermal approach developed to effectively address the thin region. Derived from adipose tissue, ACF is an extracellular matrix collagen scaffold enriched with adipokines, promoting bio-stimulation and tissue regeneration. It offers a sustained-release mechanism that enhances collagen synthesis and protects skin barrier.
Clinically, ACF represents a promising autologous filler for periorbital rejuvenation, improved skin quality, and minimized risks. ACF as a valuable regenerative solution and bring scientific messages for aesthetics and anti-aging treatments.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability