Objectives: Lecture Objectives on Secretomes
*Define secretomes and their components (growth factors, cytokines, extracellular vesicles, etc.).
*Highlight the biological processes mediated by secretomes, such as cellular communication, angiogenesis, and tissue repair.
*Discuss the differences between secretomes and regenerative therapies like exosomes or stem cell therapy.
*Explore the mechanisms of action of secretomes in tissue repair, anti-inflammation, and collagen production.
*Present their role in cellular signalling, focusing on their ability to activate dormant cells and regenerate tissue
Introduction: Definition: Secretomes are the substances secreted by cells into their surrounding environment. In regenerative medicine, the focus is on secretomes derived from mesenchymal stem cells (MSCs) or adipose-derived stem cells (ADSCs).
Components:
Growth Factors: Stimulate cell growth, proliferation, and differentiation (e.g., VEGF, TGF-β).
Cytokines: Modulate immune responses and reduce inflammation.
Extracellular Vesicles: Carry genetic material (microRNA, mRNA) and proteins to influence other cells.
Proteins and Enzymes: Aid in tissue remodeling and repair.
Materials / method: Provide an overview of how secretomes are applied in various aesthetic procedures:
Skin rejuvenation: Enhancing skin texture, elasticity, and hydration.
Hair restoration: Stimulating follicle regeneration and reducing shedding.
Scar management: Improving wound healing and reducing pigmentation.
Post-procedure recovery: Supporting tissue healing after treatments like microneedling, laser therapy, or PRP.
Showcase clinical case studies to demonstrate results and highlight best practices.
Results: Skin Aging: Studies show that secretomes from MSCs improve skin hydration, elasticity, and reduce signs of aging.
Hair Regrowth: Early research indicates that secretomes boost follicle regeneration, especially in androgenetic alopecia.
Combination Approaches: Clinical trials are exploring secretome-enhanced PRP and exosome therapies for better outcomes.
Advantages of Secretomes
Non-Invasive: Delivered via microneedling, injectables, or topicals, secretomes are minimally invasive.
Safety: Secretomes do not contain live cells, reducing the risk of rejection or immune reactions.
Potent Results:
Conclusion: Educational Takeaways
Empower practitioners with actionable knowledge to integrate secretomes into their clinical practice.
Provide a clear framework for patient selection, treatment protocols, and expected outcomes.
Inspire attendees to stay updated on scientific advancements and adopt evidence-based practices.
Disclosures
Did you receive any funding to support your research for this TOPIC?
No
Were you provided with any honoraria, payment or other compensation for your work on this study?
No
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work was not supported by any direct or non direct funding. It is under the author's own responsability
