Objectives: To show:
1. the impact on Quality of Life
2. the myths about acne
3. the connection acne with diet.
“There is no single disease which causes more psychic trauma, more maladjustment between parents and children, more general insecurity and feelings of inferiority and greater sums of psychic suffering than does acne vulgaris.” was showed by Professor Sulzberger in 1948.
Acne vulgaris is one of the most leading cause for visits to a dermatologist., and are a lot of myths about acne, including the connection acne - diet.
Introduction: Acne pathogenesis is related to several key factors: excess sebum production by the sebaceous glands, follicular occlusion, hyperproliferation of Propionobacterium acnes (P. acnes) – now is Cutibacterium acnes (C. acnes) bacteria, and inflammation.
The crossover study by Fulton (who denied the connection between acne and chocolate) was methodologically flawed by comparing chocolate and sweet vegetable oil bars that had the same glycemic index (GI). In addition, the placebo bars had higher content of partially hydrogenated vegetable fat, which may contribute to inflammation.
Materials / method: The frequent consumption of carbohydrates - the "Western diet" - which means a high glycemic index, may repeatedly expose adolescents to acute hyperinsulinemia. Acute hyperinsulinemia influences follicular epithelial growth and keratinization, as well as sebaceous secretion mediated by bovine androgens. A “Western” diet is typically rich in high glycaemic index (HGI) foods and is considered to cause chronic hyperinsulinaemia.
Results: The pathogenesis of age-related diseases of civilization such as obesity, T2DM, metabolic syndrome, cancer, neurodegenerative diseases and early aging have all been related to persistently increased activation of the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1).
Acne represent the mirror of exaggerated insulinotropic Western nutrition and a clinical and epidemiological indicator of appropriate or inappropriate human nutrition.
Conclusion: Acne is a polymorphic disease with noninflammatory and inflammatory aspects and a wide spectrum of severity. The pattern of disease, relative severity and distribution, and the patient’s social circumstances will influence management. Before treatment is undertaken, education about acne, its pathogenesis and likely outcome, as well as requirement for ongoing treatment, is required. Commonly held beliefs surrounding acne need to be rationally discussed with both the patient and their family.
Disclosures
Did you receive any funding to support your research for this TOPIC?
No
Were you provided with any honoraria, payment or other compensation for your work on this study?
No
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work was not supported by any direct or non direct funding. It is under the author's own responsability