Objectives: skin aging is a multicomponent process and some endogenous and exogenous factors have impacts on it.
A new generation of skin biorevitalizers , based on high molecular weight non-cross-linked hyaluronic acid (HA) can decelerate or reverse some components of skin aging.
In this study we are looking for better understanding of the efficiency of this biorevitalizers.
Introduction: The anti-aging effectiveness of injected hyaluronic acid is well known. We have a new generation of skin biorevitalizers with a high molecular weight (2.7-3.7∙kDa) non-cross-linked hyaluronic acid similar to that of the skin. Its deep dermal injection boosts collagen formation, enhances skin hydration, firmness, and elasticity, improves fibroblast morphology and function, and strengthens the epidermal barrier. these new biorevitalizers are manufactured with a specific technology that guarantees the final molecular weight and size as well as the ability to withstand the action of hyaluronidase
Materials / method: six volunteers with different grades of aging in the facial zone were included. in each treatment session, after facial cleaning and disinfection of the participant, the point-by-point technique was used to inject the non-cross-linked HMWHA into the dermis at a depth of ≤4 mm, with a distance of 5 mm between the injection points. Three treatment sessions spaced three weeks apart were performed. The Skin firmness and elasticity in turn were assessed with the Cutometer® and skin hydration was evaluated with the Corneometer®. High resolution before after pictures were also evaluated.
Results: The results show improved firmness (15.2%, p-value = 0.11), elasticity (66.1%, p- value=0.028), and hydration (19.8%, p-value= 0.173), evidenced by the Cutometer® and Corneometer® probes. the before/after photo based results and subjective results were satisfactory too.
Conclusion: The dermal injection of HMWHA with a molecular weight between 2.7-3.7∙kDa has proven to be effective and safe in the treatment and prevention of skin aging. Additional research involving larger samples and longer follow-up periods is required.
Disclosures
Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): Toskani
Were you provided with any honoraria, payment or other compensation for your work on this study?
Yes
Please specify entities (individual, company, society): Toskani
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
Yes
Please specify entities (individual, company, society): Toskani
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work is presented thanks to the support of: Toskani