Objectives: Objectives: The aim of this study was to evaluate the safety and efficacy of a study group (SG) regarding the use of FG-e-ASCs in breast augmentation for aesthetic improvement, comparing the results with a control group (CG) and at the same time the safety and efficacy of a study group (SG-1) regarding the use of FG-e-ASCs in breast reconstruction, comparing the results with a control group (CG-1).
Introduction: Fat graft enhanced with adipose-derived stem cells (FG-e-ASCs) has been utilized in outcomes of radiotherapy after mastectomy, breast soft tissue defects, ulcers, and loss of substance. The authors present their experience using FG-e-ASCs in breast augmentation and breast reconstruction.
Materials / method: A total of 46 patients affected by breast hypoplasia (SG) were treated with FG-e-ASCs, comparing results with those of a CG (n = 30) treated with fat graft not enhanced (FG-ne-ASCs). 121 patients (SG-1) that were affected by the outcomes of breast oncoplastic surgery were treated with FG-e-ASCs, comparing the results with the CG-1(n = 50) treated with FG-ne-ASCs. The preoperative evaluation included a complete clinical evaluation, a photographic assessment, MRI, US, and mammography. Postoperative follow-up took place at 1, 3, 7, 12, 24, and 48 weeks, and then annually.
Results: SG patients treated with FG-e-ASCs showed 58% maintenance of the volume after 3 years compared with the patients of the CG treated with FG-ne-ASCs, who showed 29% maintenance. In 67.4% (n = 31) of breast augmentation treated with FG-e-ASCs, we observed an increase of 10.3 mm in the 3D volume after 36 months, which was observed in only 20.0% (n = 6) of patients in the CG.
In 72.8% (SG-1 n = 88) of breast reconstruction treated with FG-e-ASCs, we observed an increase of 12.8 mm in the 3D volume after 12 weeks, which was only observed in 27,3% (n = 33) of patients in the CG-1.
Conclusion: The use of FG-e-ASCs was safe and effective in this series of cases performed.
Disclosures
Did you receive any funding to support your research for this TOPIC?
No
Were you provided with any honoraria, payment or other compensation for your work on this study?
No
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work was not supported by any direct or non direct funding. It is under the author's own responsability