Resumen

Objectives: To assess the efficacy of a minimally invasive peptide delivery system, independently and in combination with a glutathione-based booster (glutathione + TA + PDRN), in reducing periorbital wrinkles. Comparative analyses were conducted against established invasive treatments, including microneedling radiofrequency (RFMN) and the 1064nm picosecond Nd:YAG laser. Introduction: Periorbital wrinkles are a common focus in aesthetic dermatology, traditionally addressed through invasive treatments such as lasers and microneedling. This study evaluates a minimally invasive peptide delivery system, utilizing hydrolyzed sponges bonded with GHK tripeptide and acetyl-hexa-8-peptide. The system activates via skin-specific enzymes to deliver peptides directly into the lower epidermal layers with minimal downtime. The impact of a glutathione-based booster in enhancing peptide activation and efficacy is also investigated. Materials / method: A split-face clinical trial was conducted with 20 participants (mean age: 55.2 years). One side of the face received the peptide delivery system combined with the glutathione-based booster, while the other side received the peptide system alone. Treatments were administered weekly for five sessions. Periorbital wrinkle depth was assessed using Antera 3D imaging, and results were compared with published data from RFMN and the Nd:YAG laser. Results: - The peptide delivery system alone achieved a 8.96% reduction in periorbital wrinkle depth after five sessions, comparable to the 7.58% reduction achieved with RFMN and the 9.28% reduction reported for the Nd:YAG laser. - When combined with the glutathione-based booster, the reduction increased to 15.4%, indicating the booster’s role in enhancing peptide activation and clinical outcomes. - Both treatments were well-tolerated, with no adverse events reported, highlighting their safety and suitability for patients seeking minimally invasive options. Conclusion: The minimally invasive peptide delivery system offers a clinically effective and safe option for periorbital wrinkle reduction, with results comparable to or exceeding conventional invasive treatments. The addition of a glutathione-based booster further enhances efficacy, offering a practical and patient-friendly alternative for non-invasive aesthetic improvement.