Resumen

Objectives: 1. Understand microneedling-exosome mechanism in melanogenesis modulation. 2. Recognise safety profile in Fitzpatrick III-VI skin 3. Evaluate postinflammatory hyperpigmentation improvement via clinical case data Introduction: Postinflammatory hyperpigmentation after acne causes psychological distress in darker skin types (Fitzpatrick III-VI). Current treatments (hydroquinone, lasers) risk irritation and further dyspigmentation. I will discuss our published case report that investigates microneedling with Panax ginseng exosomes, uniquely rich in melanogenesis-inhibiting biomolecules (e.g., ginsenosides), as a regenerative alternative. The science behind this plant-derived exosome type and its potential for superior anti-inflammatory/depigmenting effects via tyrosinase/MITF pathway modulation will be explored. Materials / method: Published case report methodology: Two patients (Fitzpatrick III; baseline PIH grade 2) received 3 microneedling sessions (0.5mm needles; 3-week intervals). Topical Panax ginseng exosomes were applied post-procedure. Outcomes assessed at 1-month using postinflammatory hyperpigmentation severity scale by blinded dermatologists. Results: In the case report, both patients achieved reduction from grade 2 (mild) to grade 1 (trace) PIH. Significant pigment lightening in forehead, cheeks, and perioral regions with uniform skin tone. Independent dermatologist assessments confirmed improvement. 100% patient satisfaction; no adverse events reported. Conclusion: Microneedling with Panax ginseng exosomes safely improves postinflammatory hyperpigmentation severity in acne patients. The combination enhances epidermal repair and suppresses inflammation, offering a promising alternative for Fitzpatrick III skin.