Resumen

Objectives: To compile and critically analyze available evidence on the dermatological potential of Amazonian species, focusing on the topical or systemic effects of copaiba oil, dragon’s blood, cocoa, and açaí. A case study using a standardized açaí seed extract (Ti‑35) is included to illustrate potential clinical applications of these bioactive compounds. Introduction: The growing demand for natural ingredients in dermatology has driven scientific interest toward compounds derived from Amazonian biodiversity. Copaiba oil, dragon’s blood, cocoa, and açaí have been associated with antioxidant, anti-inflammatory, and regenerative properties. This narrative review compiles key data and presents the topical application of Ti‑35 as a practical example. Materials / method: A narrative review was conducted using PubMed, Scopus, and SciELO databases to identify studies reporting dermatological effects of four Amazonian species. Additionally, a case study was carried out: two volunteers applied a serum containing Ti‑35 twice daily for 12 weeks. Skin biopsies and 3D imaging were performed before and after treatment. Results: Literature suggests potential effects of copaiba oil in healing, dragon’s blood in dermal regeneration, cocoa in photoprotection, and açaí in oxidative stress modulation. In the case study, topical application of Ti‑35 was associated with histological changes compatible with collagen fiber reorganization and fibroblast activity, indicating possible regenerative effects. Conclusion: The evidence suggests that selected Amazonian compounds hold promise for dermatological applications. The standardized açaí seed extract Ti‑35 demonstrated safety and potential antioxidant activity. Integrating scientific research with biodiversity may support the development of sustainable and innovative dermocosmetic formulations.