Objectives: This presentation aims at explaining the complex mechanisms involved in Filler induced Collagenesis. Knowledge of these elements allows for a better understanding of the Mechanotranduction factors and of some of the adverse events encountered.
Materials / method: Knowledge of the anatomical and physiological changes induced by tension mechanisms within the skin allows us to understand the modifications in the "youth appearance" of the skin through fillers injections
Results: The concept of "tension integrity" or "tensegrity" is based on the knowledge of "mechanotransduction" mechanisms, through which mechanical forces are changed into chemical signals to modify and regulate the cells, mainly the fibroblast.
These mechanisms are well studied in wound healing, and are the same that applied to the consequences of the Foreign Body Reactions, occurring when fillers are injected within the tissues.
Conclusion: It is therefore possible to influence the skin metabolisms in order to recreate a softer, more elastic, younger skin.
But the type of the collagen produced has a major influence on the quality of the final results, and should be taken into account to avoid some or treat some complications.
Declaraciones
¿Ha recibido algún tipo de financiamiento para realizar su investigación sobre esta temática?
No
¿Ha recibido algún pago, honorario u otra compensación por su trabajo acerca de esta investigación?
No
¿Tiene vínculos financieros con alguna entidad que podría llegar a competir estrechamente con los medicamentos, materiales o instrumentos tratados en su investigación?
Si
Por favor especifique las entidades (individuo, empresa, sociedad): Sinclair Pharamceutical
¿Posee o ha solicitado una patente relacionada a los materiales, productos o instrumentos utilizados en su investigación?
No
Este trabajo no cuenta con el apoyo de ningún financiamiento directo o indirecto. El autor asume plena responsabilidad sobre el mismo.