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IMCAS Asia 2024
Programa

096

Contributed Talks - Regenerative medicine

Sala: Room 2 - Level 2
Fecha: domingo 23 junio 2024 de 16:00 a 17:00
Formato: CONTRIBUTIVA > presentaciones que fueron cuidadosamente revisadass y seleccionadas por el Consejo Científico. basadas en presentaciones y/o resúmenes recibidos

Moderadores

Dr Hugues CARTIER

Dermatólogo

Francia

Dr Diane Irvine DUNCAN

Cirujano Plástico

Estados Unidos

Las presentaciones

Horas	Oradores	Título de la presentación	Resumen	Número
16:00	Dr Fui Ping LIM	Cord Lining Mesenchymal Stem Cells (CL-MSCs) Enhance the Structure, Thickness and Alignment of Collagen in Tissues Regeneration	Ver	134623
16:12	Dr Ali Saeed AL AMRI	Exosome indications in dermatology: what’s new?	Ver	134622
16:24	Dr Piyush BHADABHAI BORKHATARIYA	Injectable PRF for anti ageing aesthetic treatment - an Asian perspective	Ver	134624
16:36		Discussion and Q&A		134625

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Exosomas

Plaquetas ricas en plasma (PRP)

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Cicatrices

Dr Fui Ping LIM

PhD - Investigación

Singapur

Otro(s) autor(es) : Assoc Prof Phan Toan Thang, Assoc Prof Alvin Chua

Cord Lining Mesenchymal Stem Cells (CL-MSCs) Enhance the Structure, Thickness and Alignment of Collagen in Tissues Regeneration

Objectives: To investigate whether the application of Cord Lining-Mesenchymal Stem Cells (CL-MSCs) improve collagen architecture, using Transmission Electron Microscopy (TEM) microscopic study to examine the collagen fiber diameter and orientation.

Introduction: Collagen, the primary protein in our skin, is essential for maintaining a smooth and firm appearance. However, collagen production diminishes as we age, resulting in visible aging signs like wrinkles, fine lines, and decreased skin elasticity. Stem cell treatments offer a groundbreaking solution to this problem. By targeting the skin at its cellular core, these treatments stimulate collagen regeneration, empowering the skin to regain its youthful structure from the inside out.

Materials / method: The study utilised 6 pigs, with 6 wounds created onto each pigs. The 6 pigs were randomly divided into three groups, with CL-MSCs delivered through (i) topical route (ii) intraperitoneal route and (iii) control group. Histopathological analysis and evaluation of collagen fibers were evaluated through Masson’s Trichrome stained photographs. The photograph were viewed and analyzed using Philips IMS v2.4 to study the collagen architectural of the tissues biopsied. Transmission Electron Microscopy was used to evaluate collagen ultrastructure, based on fiber orientation and fiber diameter

Results: The treated tissues showed accelerated collagen deposition in the granulation tissues of the CL-MSCs treated tissues. The median percentage of collagen deposition was highest for IP treated tissues. The control tissues consistently contain the lowest percentage of collagen deposition, either barely resurfaced or not resurfaced at all and with collagen ﬁbers that were loosely arranged with no dominant direction. The collagen fibers in the treated tissues were thicker and stronger in appearance, while the fibers of the control tissues were delicate and frail.

Conclusion: This study shows that the collagen fibers in tissues from CL-MSCs treated pigs were more mature in appearance. The fibers in CL-MSCs treated tissues were bundled into a neat pattern and have significantly thicker fibers as compared to control tissues. Collagen fibers from the control tissues were frail and weak in appearance, disorganized and scattered throughout all examined time points, and evidently the narrowest fibers.

Declaraciones

¿Ha recibido algún tipo de financiamiento para realizar su investigación sobre esta temática?
Si
Por favor especifique las entidades (individuo, empresa, sociedad): Cell Research Corp

¿Ha recibido algún pago, honorario u otra compensación por su trabajo acerca de esta investigación?
No

¿Tiene vínculos financieros con alguna entidad que podría llegar a competir estrechamente con los medicamentos, materiales o instrumentos tratados en su investigación?
No

¿Posee o ha solicitado una patente relacionada a los materiales, productos o instrumentos utilizados en su investigación?
No

Este trabajo no cuenta con el apoyo de ningún financiamiento directo o indirecto. El autor asume plena responsabilidad sobre el mismo.

Dr Ali Saeed AL AMRI

Dermatólogo

Arabia Saudita

Otro(s) autor(es) :

Exosome indications in dermatology: what’s new?

Objectives: This study aims to provide a comprehensive overview of exosomes' emerging role in dermatology and aesthetic medicine, highlighting their potential therapeutic applications.

Introduction: Exosomes are nanoscale vesicles derived from cells, recognized in regenerative medicine for their capability to transport diverse biomolecules such as proteins, nucleic acids, and lipids. These vesicles are key mediators of intercellular. communication, impacting critical cellular processes including proliferation, differentiation, migration, and cell death.

Materials / method: Leveraging our extensive experience in exosome-based treatments for over 2000 patients, this study synthesizes recent research to outline the mechanisms and potential applications of exosomes in various dermatological and aesthetic procedures.

Results: Exosomes show promise as therapeutic agents in a broad spectrum of dermatological and aesthetic interventions, including wound healing, scar management, skin aging reversal, facial rejuvenation, pigmentation issues, psoriasis, atopic
dermatitis, vitiligo, lupus, sclerosis, and hair growth. Their multifaceted
mechanisms offer versatile solutions for numerous dermatological conditions and aesthetic improvements.

Conclusion: The growing research on exosomes underscores their transformative potential in dermatology and aesthetic medicine. Harnessing exosomes' regenerative properties could revolutionize treatment approaches for various skin conditions and aesthetic. needs. Further research is encouraged to fully unlock their therapeutic
potential and innovate clinical applications.

Declaraciones

¿Ha recibido algún tipo de financiamiento para realizar su investigación sobre esta temática?
No

¿Ha recibido algún pago, honorario u otra compensación por su trabajo acerca de esta investigación?
No

¿Tiene vínculos financieros con alguna entidad que podría llegar a competir estrechamente con los medicamentos, materiales o instrumentos tratados en su investigación?
No

¿Posee o ha solicitado una patente relacionada a los materiales, productos o instrumentos utilizados en su investigación?
No

Este trabajo no cuenta con el apoyo de ningún financiamiento directo o indirecto. El autor asume plena responsabilidad sobre el mismo.

Dr Piyush BHADABHAI BORKHATARIYA

Dermatólogo

India

Otro(s) autor(es) :

Injectable PRF for anti ageing aesthetic treatment - an Asian perspective

Objectives: How injectable PRF is prepared & injected for anti ageing benefits. How PRF is prepared, what should be ideal centrifugation speed, type of tube for blood collection, type of centrifuge machine, how to extract PRF and how to inject in face & peri orbital area. Why PRF is superior than PRP.

Introduction: In recent years,Injectable Platelet-Rich Fibrin (PRF) has emerged as a promising therapy in dermatology, particularly in the realm of anti ageing & skin rejuvenation . As dermatologists, our pursuit of safe and effective solutions to combat the signs of aging is perpetual, and PRF presents a compelling answer to this dilemma.

This abstract aims to provide an overview of the mechanism, efficacy, and clinical applications of PRF in anti ageing & skin rejuvenation benefits.

Materials / method: • We have given injectable PRF to all patients. Bilateral intradermal injections into the malar area (1 mL each), nasolabial folds (0.5 mL each), and upper lip skin above the vermilion border (1 mL) were performed using a 32 g × 4 mm needle
• Individual 0.1-mL injections spaced 5 mm apart were administered to cover the three regions
• In total, approximately 4 mL of i-PRF in four 1-mL syringes was administered.

A 3cc PRF solution was injected into the wrinkles around the eyes with a canola number 27 on both sides.
The injection was performed at the sub-dermis site and in one session.

Results: We have compared Platelet rich plasma (PRP) with Platelet rich Fibrin (PRF) for its anti ageing benefits. We found that injectable PRF is better than PRP in producing anti ageing & skin rejuvenation benefits.
Significant improvement in several skin characteristics was mirrored by significant improvement in patient satisfaction, thereby suggesting a benefit for the use of i-PRF for facial skin rejuvenation.
Following PRF injection, in addition to improving deep wrinkles, noticeable improvement was observed in fine and small wrinkles, periocular hyperpigmentation, and overall skin freshness.

Conclusion: PRF is superior than PRP for anti ageing benefits
Liquid- injectable PRF is suitable for Facial rejuvenation & anti ageing
Centrifugation should be start within 90 seconds of blood collection
10 ml of blood required for making 1 ml of i-PRF.
i-PRF should be injected within 15 to 20 mins of preparation
PRF contains higher concentrations of platelets, fibrin, and leukocytes compared to other platelet-rich concentrates.
PRF not only represents a rich source of growth factors but also provides a scaffold to support true tissue regeneration.

Declaraciones

¿Ha recibido algún tipo de financiamiento para realizar su investigación sobre esta temática?
No

¿Ha recibido algún pago, honorario u otra compensación por su trabajo acerca de esta investigación?
No

¿Tiene vínculos financieros con alguna entidad que podría llegar a competir estrechamente con los medicamentos, materiales o instrumentos tratados en su investigación?
No

¿Posee o ha solicitado una patente relacionada a los materiales, productos o instrumentos utilizados en su investigación?
No

Este trabajo no cuenta con el apoyo de ningún financiamiento directo o indirecto. El autor asume plena responsabilidad sobre el mismo.

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IMCAS Asia 2024 Programa

096

Contributed Talks - Regenerative medicine

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IMCAS Asia 2024
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