Dr Irina POLEVA
Dermatologue
A new concept of regeneration of extracellular matrix
Objectives: To evaluate the efficacy of a new formulation based on high molecular weight hyaluronic acid, amino acids and polynucleotides for the deep injections to stimulate the connective structures of the face as ligaments and septa by regeneration of extracellular matrix, hence, to improve sagging of the face
Introduction: The ageing process involves all the structures and tissues of the face. Connective tissue with the extracellular matrix is one of the most important supporting structures mostly composed of collagen fibres which degrade with age. Inducing neocollagenesis in the subcutaneous structures by deep injections of a new formulation based on high molecular weight hyaluronic acid, amino acids and polynucleotides we suppose to slow down the ageing process
Materials / method: 15 patients with sagginess underwent 3 monthly sessions of deep injections (in the periosteal layer) of a new product. The evaluation of the outcome was made 3 months after the last session using a GAIS questionnaire (subjective evaluation) and 3D photosystem ( objective evaluation of wrinkles conditions and vectors of lifting)
Results: All the patients reported good to high satisfaction. The objective evaluation showed a tangible improvement in wrinkles conditions and light to moderate lifting effect.
Conclusion: The study showed that the new formulation based on high molecular weight hyaluronic acid, amino acids and polynucleotides is an innovative option for the regeneration of the subcutaneous connective tissue and extracellular matrix.
