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Objectives: This study evaluates the effectiveness of Pluryal Densify, both alone and with other treatments, in improving skin quality and patient satisfaction. We analyze its impact on skin tone, fine lines, wrinkles, elasticity, and radiance. Additionally, we assess how combining it with other treatments optimizes results. Introduction: BIANCA CLINIC specializes in aesthetic dermatology and plastic surgery, treating diverse patients. Due to rising demand for skin rejuvenation, the clinic frequently uses collagen boosters and injectables. Pluryal Densify, a combination of polynucleotides (PN), non-crosslinked hyaluronic acid, and mannitol, improves hydration and skin quality. This study examines its effectiveness alone and in combination with other treatments. Materials / method: We reviewed clinical cases of Pluryal Densify, used alone or with other treatments. ・Patients: Had concerns like fine lines, pigmentation, and erythema. ・Treatment: Administered every 2-4 weeks over three sessions. ・Combination Therapy: Some patients received laser or microneedling. ・Evaluation: Assessed through before-and-after images and patient feedback on skin texture, hydration, and tone. Results: ・Pluryal Densify alone improved skin tone, wrinkles, and radiance, with high patient satisfaction. ・Combination treatments further enhanced pigmentation and erythema reduction. ・Most patients saw long-lasting improvements, and over 75% wanted to continue treatment. ・No serious side effects were reported, confirming its safety. Conclusion: Pluryal Densify effectively improves skin hydration, elasticity, and quality. While effective alone, combination treatments enhance patient satisfaction and results. This study suggests Pluryal Densify is a safe, versatile option for aesthetic practitioners seeking better skin rejuvenation outcomes.