Objectives: We observed significant improvements in pigmentation and pore size compared to baseline. Additionally, there were noticeable improvements in nasolabial folds, marionette lines, and acne scars post-treatment. The highest levels of improvement were observed at week 4, followed by a gradual decrease over time. No serious adverse effects were reported, apart from mild procedural pain (3.5/10 on the pain scale) and transient redness that resolved within 1–2 days.
Introduction: Platelet-Rich Plasma (PRP) has long been recognized as one of the leading solutions for addressing skin aging concerns. Numerous studies have highlighted the exceptional role of PRP in treating wrinkles, enlarged pores, skin hydration, and hair loss. In recent years, Platelet-Rich Fibrin (PRF) has emerged as a promising new agent. However, research on the combined use of PRP and PRF remains limited, and the techniques for utilizing PRF in aesthetic dermatology have not been fully elucidated. Therefore, this study was conducted to explore these areas further.
Materials / method: We conducted a study involving 10 patients who underwent a combination of PRP and PRF treatments using the BAP injection technique specifically for the facial area. Patients were assessed using VISIA imaging at baseline (prior to treatment) and at 2 weeks, 4 weeks, 8 weeks, and 12 weeks post-treatment. Eight parameters were evaluated through VISIA, including spot, UV spot, brown spot, wrinkles, redness, porphyrins, texture, and pores. Additionally, we assessed the improvement in forehead wrinkles, crow’s feet, cheek wrinkles, nasolabial folds, marionette lines, and acne scars.
Results: The brown spots index had a mean baseline value of 68.4% (n=10), peaked at 77.2% (n=10) at week 4, and gradually decreased to 67.9% (n=10) at week 8 and 64.14% (n=7) at week 12. Similarly, the pore index showed a mean baseline value of 30.3% (n=10), steadily increasing to 37.4% (n=10) at both week 4 and week 8, before declining to 32.57% (n=7) at week 12. The highest levels of improvement were observed at week 4, followed by a gradual decrease over time. No serious adverse effects were reported, apart from mild procedural pain (3.5/10) and transient redness that resolved within 1-2 days
Conclusion: The combination of PRP and PRF shows promising potential in improving skin surface conditions, including pigmentation, enlarged pores, and acne scars, as well as addressing other signs of skin aging such as nasolabial folds and marionette lines. The BAP injection technique is a suitable approach for PRF due to its simplicity, minimal pain, and quick application, which prevents PRF from transitioning into a solid state. Further studies are needed to validate the efficacy of the PRP-PRF combination and to optimize PRF injection techniques in aesthetic dermatology.
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