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Objectives: L earn the possible application of Exosomes in Sexual medicine E xplore what we have learned about the different sources of exosomes A nalyse the significance of "number of Exosomes" R eview data from case studies in Men and Women N ever wonder again about the purpose, use, or power of exosomes as the key to all regenerative therapies Introduction: Are you sure you understand what all the craze is about when it comes to Exsomes? Learn whether plant, fetal, platelet, or adipose derived exosomes make a difference. Can topical use using microneedling be as affective as injecting the exosomes? Explore how Exosomes can enhance results in sexual medicine applications exhancing erectile effects in men and orgasmic response in women. Materials / method: Case studies will be presented utilizing multiple different sources of exosomes. Plant, adipose, and autologous exosmes are used to enhance sexual function and in aesthetic vulvar applications. Results: Exosomes enhance the results as defined by the FSFI and the SHIM score for sexual function. They diminish downtime and ease discomfort following procedures. Due to having off the shelf availability, they may improve the ease of the procedures enabling more providers to perform these life changing treatments. Conclusion: Exosomes are becoming more available but this also leads to confusion and can be overwhelming to providers interested in entering this space. By simplifying the known facts now available, and describing the benefits and regenrative power, the goal is to encourage more providers to feel comfortable to use exosomes for sexual health and beyond.