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Objectives: Hand Rejuvenation in Aesthetic Dermatology: Evidence-Based Approaches and Treatment Strategies To review evidence-based approaches for hand rejuvenation in aesthetic dermatology and to discuss multimodal treatment strategies, including injectables and laser-based technologies, aimed at addressing structural changes and improving skin quality through a comprehensive and individualized approach. Introduction: Hand aging is characterized by volume loss, skin thinning, pigmentary alterations, and increased visibility of tendons and veins. Despite their aesthetic relevance, the hands are often under-treated in rejuvenation protocols. Evidence-based and multimodal strategies, including laser-based technologies, are essential to achieve balanced and natural outcomes. Materials / method: This presentation is based on a review of current literature combined with clinical experience in aesthetic dermatology. Treatment modalities include biostimulatory injectables, soft tissue fillers, and laser-based technologies targeting pigmentation, texture, and skin quality. Emphasis is placed on patient stratification according to age-related changes and primary aesthetic concerns, guiding individualized treatment planning. Results: Multimodal treatment strategies demonstrate improvements in hand volume, skin texture, pigmentation, and overall skin quality. The combination of injectables and laser-based therapies allows synergistic effects, supporting natural-looking rejuvenation while maintaining favorable safety profiles. Conclusion: Hand rejuvenation benefits from an evidence-based and multimodal approach. The integration of injectables and laser-based technologies enables comprehensive treatment of both structural and skin quality changes, supporting individualized strategies and consistent, natural aesthetic outcomes.