Objectives: Understand the unique challenges of neck wrinkle treatment and the importance of patient-specific approaches.
Explore the advantages of dermal fillers made using the supercritical decellularization process, including enhanced safety, structural integrity, and natural volume restoration.
Evaluate clinical and histological outcomes, such as collagen stimulation and improved skin elasticity.
Compare advanced injection techniques, including needle-free jet injectors, for safe and effective results.
Gain practical skills in patient selection and evidence-based neck rejuvenation strategies.
Introduction: Horizontal neck wrinkles are difficult to treat due to thin skin, repeated movement, and reduced dermal support. This study introduces a novel approach using a dermal filler composed of acellular dermal matrix (ADM) processed via supercritical decellularization. The method aims to safely restore volume and stimulate collagen without the complications of synthetic fillers.
Materials / method: Twenty patients with moderate-to-severe neck wrinkles received 2–3 sessions of 8% ADM filler injection using either a 30G needle or needle-free jet injector at 4-week intervals. No anesthesia or pretreatment was required. Clinical photos, 3D imaging, and GAIS were used to evaluate outcomes. Histological analysis was conducted on biopsy samples from consenting subjects.
Results: Significant improvement in wrinkle depth, skin texture, and elasticity was observed after 1–2 months. GAIS scores averaged 4.3/5. No Tyndall effect, nodule formation, or delayed reactions were reported. Histology showed increased fibroblast activity and neocollagenesis. The ADM filler demonstrated excellent tissue integration with no phase separation during injection.
Conclusion: Supercritical ADM fillers provide a safe and biologically active solution for neck rejuvenation. Unlike HA or CaHA, ADM delivers immediate structural support and collagen-rich dermal integration. This technique offers a reproducible and non-bulky approach to treating delicate neck folds, with both clinical and histological benefits confirmed.
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