Objectives: The medical aesthetics industry has focused on dermal rejuvenation, but epidermal health, which is directly influenced by the dermal-epidermal junction (DEJ), is equally crucial. As we age, the DEJ flattens, weakening the connection between the epidermis and dermis, affecting skin resilience, hydration, and renewal. This presentation will review a retrospective case study and real-world clinical cases that followed a DEJ-focused protocol across diverse age groups and ethnicities, highlighting its potential for optimizing skin rejuvenation treatments.