Objectives: 1). To characterise the skin microbiome
2). To examine how the microbiome differs between dry and non-dry skin
3). To understand how the skin microbiome changes in response to treatment
Introduction: Considerable work has been invested in understanding the composition of the skin microbiome, how this differs between body sites and changes in medical conditions.
However, despite its high prevalence in society, little work has been undertaken to investigate the microbiome of dry skin and to understand how this changes in external challenges.
Materials / method: Cohort studies were undertaken in two geographically distinct locations (European
and North American) wherein a total of 222 subjects were recruited and lower leg skin classified as dry or non-dry based on visual assessment. Microbiome protocols employed to extract and analyse the microbial 16S rRNA gene prior to taxonomic, diversity and network analysis of microbiome data.
Results: All measures revealed a high degree of consistency between the two geographic cohorts. Staphylococcus, Cutibacterium, and Corynebacterium were the dominant genera in both cohorts and both skin types. Significant differences in microbiome diversity were observed using some metrics and microbiome network analysis demonstrated that in both cohorts the microbiome of dry skin exhibits decreased connectivity and resilience relative to that of non-dry skin.
Conclusion: This is the first study of the dry skin microbiome to compare large cohorts of subjects across multiple geographies. In contrast to previously published studies which used small cohorts, this study found no difference in α-diversity between dry and normal skin. Instead, this study found clear and consistent differences in microbiome β-diversity and network co-occurrence. These changes suggest that the microbiome of dry skin is compromised, exhibiting decreased connectivity and increased fragility relative to the microbiome of non-dry skin.
Divulgação de informações
Você recebeu algum patrocínio para sua pesquisa neste tema?
Sim
Por favor indique a entidade (pessoa ou empresa): Research supported by Unilever R&D
Você recebeu algum tipo de honorário, pagamento ou outra forma de compensação por seu trabalho neste estudo?
Sim
Por favor indique a entidade (pessoa ou empresa): Salary as an employee of Unilever
Você possui relação financeira com alguma entidade que possa competir com os medicamentos, materiais ou instrumentos abordados no seu estudo?
Sim
Por favor indique a entidade (pessoa ou empresa): Unilever R&D
Você detém ou pediu a registro de patente para algum dos instrumentos, medicamentos ou materiais abordados no seu estudo?
Não
Este trabalho foi realizado com o patrocínio de: Unilever R&D
