Objectives: Currently, fat is one of the most important tools in Aesthetic and Reconstructive Plastic Surgery. In fact, it has changed the approach of multiple treatments and protocols in the last decade. Nanofat is a new procedure derived from emulsifying the fat and injecting it into the dermal layer. The authors describe how to harvest the fat with a closed loop that they have developed, and their experience with nanofat technique. The procedure, clinical applications, cases reports, and tissue studies to evaluate its stem cell content will be explained.
Introduction: The nanofat technique was performed to the skin of cheeks, nasolabial folds, neck, hands, neckline and in particular to correct the color of dark circles in combination or not with micrograft to treat the nasal groove.
Materials / method: For the infiltration of nanofat we used a needle of 27G, The infiltrated quantity of nanofat varied depending on the area to be treated. The infiltration of nanofat was performed at the subdermal level. The emulsified tissue was evaluated with flow cytometry to determine the viability of the cells in the product of this emulsified fat.
Results: All clinical cases showed significant improvement from 3 to 6 months after treatment. There were no major complications or undesirable effects. There was only 1 minor complication (inflammatory hyperpigmentation). With the use of flow cytometry, we have demonstrated that viable mesenchymal stem cells were present in the emulsified fat
Conclusion: Nanofat looks like an effective tool for skin rejuvenation. We have observed a significant improvement in the quality and elasticity of the skin, decrease in fine wrinkles and pigmentation in areas such as dark circles. The use of a closed circuit avoids direct manipulation,. The physiological mechanism of nanofat through which these positive results are obtained has not yet been fully elucidated; Stem cells activity, exoxomes, cytokines, apoptosis or even the paracrine effect of stem cells derived from adipose tissue (ADSC) cannot be ruled out as a mechanism of action.
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