Objectives: The objective of this study is to examine the biochemical, nutritional, and lifestyle contributors to hair loss and evaluate the role of multimodal therapy in managing non-cicatricial alopecia. Specifically,
it aims to:
-Identify metabolic and nutritional deficiencies—such as elevated triglycerides, cholesterol, and deficiencies in Vitamin D3, Vitamin B12, and iron—potentially linked to hair loss, with a focus on gender differences.
-Assess the efficacy of an integrative treatment approach that combines autologous multi-spin PRP, topical minoxidil, oral finasteride, and lifestyle adjustments
Introduction: This study investigates hair loss as a condition influenced by various factors, including genetics, nutrition, and lifestyle, aiming to evaluate both biochemical assessments and the efficacy of multimodal therapy.
Materials / method: Laboratory Analysis:Blood samples from 594 patients were analyzed after an 8-hour fast to assess triglycerides, cholesterol, Vitamin D3, Vitamin B12, and iron levels, exploring metabolic and nutritional contributors to hair loss.
Multimodal Therapy: A subset of 350 patients were selected, classified by Norwood-Hamilton and Ludwig scales, received eight sessions of therapy including PRP, topical minoxidil, and oral finasteride along with nutritional deficiencies corrections (if) required, along with life style modifications to target non-cicatricial alopecia.
Results: Laboratory Findings: High levels of triglycerides and cholesterol were prevalent among male patients, indicating a possible link to hair loss. Vitamin D3, Vitamin B12, and iron deficiencies were common, especially among males, underscoring nutritional factors in hair loss.
Therapy Outcomes: Noticeable improvements in hair density and diameter were achieved in patients with lower-grade alopecia. Advanced cases (Grades 6-7 in males and Grade 3 in females) showed moderate improvement, reflecting mixed patient satisfaction.
Conclusion: Laboratory screening for metabolic and nutritional deficiencies in patients with hair loss is valuable. The effectiveness of multimodal therapy reinforces the importance of a comprehensive approach, combining multiple spinning PRP, pharmacologic, and lifestyle modifications to manage non-cicatricial alopecia.
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