Абстракт

Objectives: Polydeoxyribonucleotides (PDRNs) are naturally occurring polymers comprised of deoxyribonucleotides linked by phosphodiester bonds. PDRNs derived from various sources, including salmon, have gained significant attention in aesthetics due to their potential regenerative and anti-aging properties. This paper aims to explore the utilization of salmon-derived PDRNs in aesthetic medicine, focusing on their mechanisms of action and specific applications in skin rejuvenation. Introduction: PDRNs are a type of nucleic acid composed of deoxyribonucleotide monomers, which are the building blocks of DNA. PDRNs extracted from salmon generally consist of 10 to 50 nucleotides and their the specific functional properties are still being studied, but they have been found to have various biological activities, such as immune modulation, anti-inflammatory effects, and promotion of cell regeneration. These properties make PDRNs potential candidates for an effective therapeutic applications in medicine and skincare. Materials / method: PDRNs promote the growth and activity of fibroblasts. Approximately 54,55 fibroblasts are located in the dermal layer, suggesting that PDRNs must be administered directly into this layer to obtain maximum benefits. In this case, some applications are: a)Facial rejuvenation: Use of salmon PDRNs in dermal fillers, mesotherapy, and microneedling b)Hair restoration: To promote hair growth and preventing hair loss c)Wound healing: Acceleration of tissue repair and scar reduction d)Hand and body rejuvenation: Application of salmon PDRNs in addressing age-related skin changes Results: PDRNs derived from salmon DNA have been shown to have various biological properties such as anti-inflammatory, wound healing, and tissue regeneration effects and may continue to be explored for their potential applications in aesthetic medicine. Some side effects have been observed like allergic reactions, hypersensitivity, as swelling, redness, pain, or bruising at the injection site. However, these side effects are generally temporary and resolve within a few days. It is important to note that the side effects mentioned above are not exhaustive, and individual responses may vary. Conclusion: Salmon-derived PDRNs have demonstrated a generally good safety profile in aesthetic use. However, it is crucial for healthcare professionals to conduct thorough evaluations and follow established guidelines to ensure patient safety and minimize potential risks and get good results. In conclusion, the future perspectives of salmon PDRN in aesthetic use hold promise for skin rejuvenation even combined with collagen biostimulator, hair growth factors, to stimulate collagen synthesis, promoting skin rejuvenation and reducing the signs of aging.