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Objectives: This article explores the application of needle free injection technology (NFIT) for the treatment of acne scars, stretch marks, and skin tightening using round Poly-L-Lactic Acid (PLLA), Poly-D-Lactic Acid (PDLLA), Calcium hydroxyapatite (CaHA) and Botulinum Toxin (BTX). The study aims to investigate the safety, efficacy, and patient satisfaction associated with this innovative approach. Introduction: NFIT is a diverse field of drug delivery systems that eliminate the need for hypodermic needles. This technology offers advantages such as reduced pain, improved patient compliance, and the potential to deliver highly viscous drugs. NFIT has garnered attention from the pharmaceutical industry and organizations like the World Health Organization and the Bill and Melinda Gates Foundation due to its potential in mass immunization programs and the prevention of needle stick injuries. This article focuses on NFIT's application in treating acne scars, stretch marks, and skin quality. Materials / method: The study employs microdriplet injection techniques with PDLLA and CaHA to address the side effects of acne and improve skin texture. Additionally, the study evaluates the effectiveness of this method in reducing wrinkles and enhancing skin texture without using BTX. The research assesses patient outcomes, safety, and the duration of potential side effects such as bruising following PDLLA and CaHA microdriplet injections. Results: NFIT makes it possible to speed up the procedure very quickly. NFIT is a revolution in injection methods. The study findings reveal that microdriplet injections using PDLLA and CaHA effectively treat the side effects of acne, though some bruising may occur, lasting up to a week on the abdomen. Furthermore, the study demonstrates a potential method to achieve results similar to micro-Botox without using BTX, leading to wrinkle reduction and improved skin texture. Conclusion: The application of NFIT for the treatment of acne scars and skin tightening using round PLLA, PDLLA, and BTX offers a promising approach to improve patient comfort and safety. The speed of the procedure is greatly increased and the patient's fear of vanol is reduced. This method has been shown to significantly improve the appearance of acne scars and stretch marks and reduce wrinkles. This study contributes to the growing knowledge surrounding NFIT and its potential application, providing a less invasive and patient-friendly alternative to traditional injection methods