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Objectives: This study seeks to assess the efficacy and safety of combination and multifocal fractional picosecond Nd:YAG laser in treating acne scars Introduction: Acne vulgaris ranks among the most prevalent skin conditions, may persisting for years without appropriate intervention. The chronic inflammatory response within the pilosebaceous unit can lead to permanent pigmentary and scars . The multifocal DOE fractional picosecond laser, represents the latest advancement in acne scar treatments. This high-fluence beam columns, inducing Laser Induced Optical Breakdown (LIOB) at uniform depths. We introduce a combination of Microneedle Radio Frequency and Fractional Picosecond laser in the treatment of acne scars at the same session Materials / method: The study enrolled 30 Asian patients from both genders residing in the tropical zone. Participants underwent six laser treatment sessions at four-week intervals. The regimen included Microneedles Radio Frequency and Fractional Picosecond 1064 nm Laser treatments employing fractional DOE handpieces with focal length 0 mm that can also ablate the acne-scarred skin. The Global Acne Scar Severity Scale (GASSS) was utilized for efficacy and safety evaluations at each visit, and at four, eight, and twelve weeks post the final treatment. Results: All patients exhibited notable improvements in the global improvement scores at week 4, 8,12,16,20 and 24 (4 weeks after the last treatment ) with each follow-up showing enhanced results compared to the baseline. The improvement become more subtle after week 16. These improvements encompassed enhancements in skin tone, texture, and the depth of acne scars. Conclusion: The synergistic use of Microneedles Radio Frequency along with fractional picosecond 1064 nm laser treatment, is both safe and effective for the treatment of acne scars in South East Asian patients