Абстракт

Objectives: -Understand exosomes' role in intercellular communication and their promise for skin regeneration and wound healing -Evaluate exosomes as innovative treatments for inflammatory and autoimmune skin conditions -Identify challenges such as standardization issues, preclinical model limitations, and the need for comprehensive safety evaluations -Focus on improving exosome purification, understanding their diversity, and establishing robust regulatory frameworks -Stress the importance of rigorous clinical validation and enhanced regulatory oversight to fully realize exosome potential in dermatology Introduction: Exosomes, nanoscale vesicles (30–150 nm) with a lipid bilayer,have emerged as crucial elements in dermatology due to their role in intercellular signaling &their potential as cell-free therapeutics.Rich in proteins, lipids& nucleic acids, these vesicles retain the biological properties of their source cells and offer promising advancements in skin regeneration,wound healing &management of inflammatory & autoimmune skin disorders.Recent research underscores their ability to bridge medical &cosmetic dermatology,highlighting the need for further exploration to unlock their full clinical potential Materials / method: Literature Review: Reviewed peer-reviewed articles in dermatology from PubMed, Google Scholar, and Scopus. Content Analysis: Analyzed dermatology content from PubMed, ResearchGate, Google Scholar, and professional dermatology forums, categorizing it and assessing engagement with analytics tools. Results: Exosomes in dermatology show promise for skin regeneration, wound healing, and managing inflammatory and autoimmune conditions. They enhance scar treatment, promote hair growth, and aid in wound recovery. Derived from sources like stem cells and dermal papillae, they improve skin conditions and reduce scarring. However, challenges in isolation standardization and long-term safety need addressing. Despite these hurdles, ongoing research suggests that exosomes could revolutionize dermatological treatments with their unique therapeutic capabilities. Conclusion: Exosomes are revolutionizing dermatology, bridging the gap between potential and application. They play a significant role in skin regeneration, wound healing, and treating inflammatory and autoimmune skin diseases. Stem cell-derived exosomes offer innovative solutions with reduced risk compared to direct stem cell therapies. However, challenges in purification, standardization, and regulation remain. Future research must address these issues to fully realize exosomes' therapeutic potential and ensure their safe clinical use.