Цели: Nevus of Ota (Oculodermal melanocytosis) is a dermal melanocytic hamartoma that presents in childhood or at adolescence as bluish/slate gray hyperpigmentation along the first or second branch of trigeminal nerve. The pigmentation progressively increases in size and color till puberty. To understand the presentation, prognosis and treatment of Nevus of Ota. Also how to deal with some difficult situations in this condition. Will be introducing some additional maneuvers to hasten the clearance of pigment in nevus of ota patients. Введение: Laser technology – Wonder of present-day therapeutics. Tremendous advances have happened since Ruby Laser was used for the first time. Goldman in 1960s used a Q-switched ruby laser (50-microsecond pulse duration) and found that the damage threshold of pigmented lesions was independent of skin color. Q-switched Nd:YAG laser (QSNYL) has been used successfully to treat nevus of Ota lesions. Most of the patients do well However, there are some cases that pose challenges Материалы / методы: We did a study to assess the efficacy and safety of Q Switched Nd:YAG Laser (QSNYL) in an open labeled prospective study involving 44 Indian patients with nevus of Ota. In 10 years >100 patients taken up for treatment of various pigmented lesions. Most of the patients have completed treatment while some are still on it. Total Patients - 105 Nevus of Ota - 44 PEN - 46 Freckles /Lentigenes - 11 Becker Nevus - 04 We used different maneuvers like an additional pass of fractional CO2 and different spot sizes for the QSL. Результаты: Total patients - 44 50 to 75 % clearance - 31 25 to 50 % clearance - 10 < 25 % clearance - 03 Nevus of Ota Total patients - 44 50 to 75 % clearance - 31 25 to 50 % clearance - 10 < 25 % clearance - 03 Заключение: Several pigment-specific lasers can effectively treat epidermal and dermal pigmented lesions. Lasers are most effective in treating epidermal pigmented lesions (eg, lentigines, ephelides). Nevus of Ota is unique amongst the pigmented dermal lesions in that near-total clearance is often seen after laser treatment. QS Lasers are the treatment of choice for the treatment of NOO These lasers have revolutionised the prognosis of this otherwise difficult to treat condition The addition of CO2 fractional laser pass and mutiple spot sizes of QSL helps clear the pigment faster and more effectively