Абстракт

Objectives: Scalp threading is a novel treatment that stimulates the hair follicle cells proliferation, extends the anagen phase of hair growth and upregulates the growth factors. Threads are inserted in the scalp for the purpose of prolonged hair follicle stimulation. A single application of threads results in significant hair growth. And combining scalp threading with additional complimentary treatments, optimizes the treatment results in hair regrowth. Introduction: Cochrane review reports that the efficacy of finasteride and minoxidil for AGA varies between 40% and 60%, which implies that a significant number of patients go bald despite therapy. The efficacy of the conventional therapies with respect to new hair growth is unsatisfactory. Scalp threading, growth factors and peptides, DFCM with MPF, mesenchymal stem cells from autologous micrografts, PRP etc. that act on stem cells and signaling pathways and regenerate and reactivate the hair follicle, are the future in hair regrowth strategies. Materials / method: Various techniques of thread applications in the scalp and adequate combination of different threads were used to achieve maximum hair regrowth. Patients with early stage AGA were treated with only scalp threading. For patients in advanced stages of androgenetic alopecia, different additional treatments were implemented, including growth factors mesotherapy, mesenchymal stem cells from autologous micrografts, DFCM with MPF, PRP, minoxidil etc. The evaluation of the hair regrowth results included before-after photos, before-after trichoscopy images and patient's satisfaction survey. Results: The before-after photos and trichoscopy images, shows significant improvement in the hair regrowth. The photos show improvement from 30% , 50% up to 70% after three and six months and nine month accordingly. The results are superior when combining treatment methods, with best results achieved with scalp threading and mesotherapy with growth factors/multi peptide factors. The patient's satisfactory survey shows that 60% were extremely satisfied, 20% very satisfied, 15% satisfied, 5% not satisfied. Conclusion: Considering its long-lasting and stimulation potential and results achieved, scalp threading can be considered to be a good treatment option for patients with alopecia androgenetica. Single application of threads, results in hair growth comparable to that achieved with consecutive applications of minoxidil. Hair count increases from average number of 65 hair follicular units to 93 hair follicular units per cm2. Combining scalp threading with different treatment methods allows for optimal hair regrowth and high patient's satisfaction rate.