Абстракт

Цели: This review aims to evaluate the combined efficacy of exosomes and PDRN in treating skin aging induced by oxidative stress. By exploring their mechanisms of action, the review highlights their potential to mitigate reactive oxygen species (ROS)-induced damage, promote collagen production, and enhance skin regeneration. Введение: Oxidative stress is a key factor in skin aging, caused by an excess of reactive oxygen species (ROS) that damage cellular structures. This process accelerates collagen degradation, inflammation, and loss of elasticity. Emerging therapies such as exosomes and PDRN offer innovative solutions by combating oxidative damage and promoting tissue regeneration. Материалы / методы: Recent literature, including clinical trials and experimental studies, was reviewed to evaluate the efficacy of exosomes and PDRN in skin aging. Key metrics such as collagen synthesis, inflammation reduction, and extracellular matrix regeneration were analyzed. The review also integrates lifestyle factors such as diet, antioxidants, and sun protection. Результаты: Exosomes effectively reduce inflammation and stimulate fibroblast activity, while PDRN enhances angiogenesis and extracellular matrix repair. Combined, they deliver superior results in improving skin elasticity, reducing wrinkles, and reversing oxidative damage. Lifestyle interventions further amplify these effects, optimizing therapeutic outcomes. Заключение: The integration of exosomes and PDRN into dermatological practice represents a breakthrough in addressing oxidative stress-induced skin aging. Their synergistic effects, combined with healthy lifestyle habits, offer a holistic approach to prevention and treatment, setting a new standard for regenerative therapies.