Абстракт

Objectives: 1.To evaluate the comparative efficacy of ASC-exosome treatment improving postoperative scar. 2.To characterize time-dependent improvement using Vancouver Scar Scale, Observer and Patient Scar Assessment Scale 3.To investigate the temporal progression of therapeutic effects from early-phase improvements to sustained enhancements with ASC-exosome intervention. 4.To identify scar parameters unaffected by ASC-exosomes treatment to define its scope of therapeutic action. Introduction: Exosomes have emerged as a promising therapeutic agent for various dermatological conditions, including acne, atopic dermatitis, and wound healing. This study aims to evaluate the efficacy of exosome in improving postoperative scar appearance and texture following revision rhinoplasty with costal cartilage, which results in a scar on the anterior chest. Materials / method: The patients undergoing revision rhinoplasty with autologous costal cartilage, each presenting with a 3 cm incision scar of anterior chest, were enrolled in this study. This study was conducted by a postoperative scar mean 4.3 months after surgery, divided into medial and lateral halves. It involved 10 patients with exosomes (ASC-exosome) and control (Hyaluronic acid) applications, evaluated using the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS). Results: Experimental group showed significant improvement in key parameters vs control group.OSAS reduced pigmentation, improved pliability of VSS by week 3 and OSAS by week 4. Relief improvement of OSAS by week 4 to 8. No differences in vascularity, height, or thickness. PSAS indicated significant improvements in scar color by week 4, stiffness by week 3, thickness by week 2. Irregularity showed significant difference at week 4 and 8. No difference in pain or itching. Conclusion: The application of exosomes significantly enhances scar quality, particularly in terms of pigmentation, pliability and relief. These findings suggest that exosomes hold considerable potential as a therapeutic option for postoperative scar management.